PMID: 8980940Dec 1, 1996Paper

Value of technetium-99m HMPAO-labelled leucocyte scintigraphy as an initial screening test in patients suspected of having inflammatory bowel disease

European Journal of Gastroenterology & Hepatology
M H GiafferD Holdsworth

Abstract

This study was designed to evaluate the role of technetium-99m (99mTc) hexamethyl propylene amine oxime (HMPAO)-labelled leucocyte imaging as an initial screening test in patients suspected of having inflammatory bowel disease (IBD). Thirty-one patients in whom a final diagnosis of irritable bowel syndrome (IBS) was made (group 1) and another 33 patients with established Crohn's disease (group 2) were studied. All patients had 99mTc HMPAO-labelled leucocyte scan with imaging at 40 and 120 min. Scans with abnormal bowel uptake were considered positive and this uptake was quantified by visual grading and computer-based methods (scan score). Group 1 patients with positive 99mTc HMPAO scan underwent an indium-111 (111In)-labelled leucocyte scan (imaging at 180 min) followed by endoscopy and barium radiology as deemed necessary in order to verify the 99m Tc HMPAO result. Three scan patterns were seen: well localized and unequivocally positive scans at both 40 min and 2 h were obtained from 28 patients. All but one had established Crohn's disease. Diffuse bowel uptake was seen in 14 scans. Ten of these (false positive) were obtained from symptomatic patients with IBS and four (false negative) from patients with asymptomatic Crohn's d...Continue Reading

Citations

Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Alessio AnnovazziAlberto Signore
Sep 13, 2000·Clinical Nuclear Medicine·M Charron
Jun 13, 2009·World Journal of Gastroenterology : WJG·Maria I StathakiIoannis E Koutroubakis
Jul 30, 2010·European Journal of Pediatrics·Federico CaobelliRaffaele Giubbini
Aug 20, 2003·Radiology·Ioannis E KoutroubakisElias A Kouroumalis
Jun 5, 2007·Seminars in Nuclear Medicine·James Claude Warrington, Martin Charron
Sep 29, 2005·Inflammatory Bowel Diseases·Carmen CuffariGary R Lichtenstein
Nov 16, 2016·World Journal of Radiology·Federico Caobelli Young Aimn Working Group
Dec 23, 2003·Clinical Nuclear Medicine·Juan Pablo Suárez FernandezLucía García
Feb 15, 2007·Current Treatment Options in Gastroenterology·Kim L Isaacs

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