Value of the Ber-EP4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma. The M.D. Anderson experience and a critical review of the literature

American Journal of Clinical Pathology
Nelson G Ordóñez

Abstract

Although most studies have indicated that Ber-EP4 immunostaining can assist in differentiating epithelial pleural mesotheliomas from adenocarcinomas that metastasize to the pleura, the percentage of positive cases has varied greatly among different studies. Authors of a recent publication concluded that Ber-EP4 has no diagnostic utility in separating these conditions. To determine whether Ber-EP4 has any value in distinguishing mesothelioma from adenocarcinoma, 70 formalin-fixed epithelial pleural mesotheliomas, 20 pulmonary adenocarcinomas, 59 nonpulmonary adenocarcinomas, 4 squamous cell carcinomas of the lung, 6 transitional cell carcinomas, and 31 adenocarcinomas of unknown origin that metastasized to the pleura were stained with this antibody. Reactivity was observed in 18 (26%) of 70 mesotheliomas and in all 20 (100%) of the pulmonary adenocarcinomas, in 55 (93%) of the 59 nonpulmonary adenocarcinomas, in 4 (100%) of 4 squamous cell carcinomas of the lung, in 4 (67%) of 6 transitional cell carcinomas, and in 26 (84%) of 31 adenocarcinomas of unknown origin that metastasized to the pleura. The staining in the mesotheliomas was focal and restricted to a limited number of cells, in contrast with staining in the pulmonary ade...Continue Reading

Citations

Jan 26, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·V DovinerY Sherman
Mar 6, 2007·Virchows Archiv : an International Journal of Pathology·Kelly J ButnorUNKNOWN Association of Direstors of Anatomic and Surgical Pathology (ADASP)
Feb 11, 2010·Diagnostic Cytopathology·Atef HannaClaire W Michael
Jun 9, 2015·Cytometry. Part B, Clinical Cytometry·Maria AcostaMaria Arroz
Jan 4, 2019·Archives of Pathology & Laboratory Medicine·Gabriel Habermehl, Jennifer Ko
Aug 11, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·R L Zimmerman
Aug 11, 2000·Pathology Oncology Research : POR·P AthanassiadouP Athanassiades
Dec 7, 2005·The American Journal of Surgical Pathology·Alison M WinstanleyMargaret C Parkinson
Aug 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nelson G Ordóñez
Jan 18, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nelson G Ordóñez
Apr 19, 2013·American Journal of Clinical Pathology·Nelson G Ordóñez
Dec 17, 2016·Clinical Case Reports·Roxanne M Rodriguez GalarzaEva Abarca
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karine LlinaresMarie-Christine Copin
Mar 24, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hadi YazijiAllen M Gown
Jul 17, 2008·International Journal of Colorectal Disease·Wilfrido D MojicaNorma Nowak
Nov 1, 2006·Advances in Anatomic Pathology·Saul Suster, Cesar A Moran
Mar 1, 2012·Archives of Pathology & Laboratory Medicine·Sisko Anttila
Dec 6, 2006·American Journal of Clinical Pathology·UNKNOWN Association of Directors of Anatomic and Surgical Pathology
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karine Passebosc-FaureChristian Genin
Feb 19, 2021·CytoJournal·Vinod B Shidham, Lester J Layfield
Mar 18, 2021·Revista española de patología : publicación oficial de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Citología·Cristina Díaz Del ArcoMª Jesús Fernández Aceñero
Jan 18, 2007·Archives of Pathology & Laboratory Medicine·Robert L Hutton, Scott R Dalton
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Larry J Fowler, Whitney A Lachar
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Khush MittalW G McCluggage
Oct 29, 2005·Archives of Pathology & Laboratory Medicine·Nelson G Ordóñez
May 24, 2006·Clinics in Chest Medicine·John C English, Kevin O Leslie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Nelson G Ordóñez
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Nelson G Ordóñez
© 2021 Meta ULC. All rights reserved