Jan 1, 1975

Value of the "gastric chamber", new technic performed ex vivo, for the study of the gastric mucosa of the rat

Comptes rendus des séances de la Société de biologie et de ses filiales
C LabridC Boero

Abstract

The "gastric chamber" technique, performed in the anaesthetised rat, enables the study of gastric mucosal fragility induced by doses of phenylbutazone, which do not themselves cause ulceration or exulceration. The perfusion of buffered solution at pH 2-8 into the gastric chamber shows that prior oral administration of phenylbutazone 50 mg/kg increases the fragility of the mucosa. The optimal delay separating this administration from the time of experimentation is 6 hours. The effects seen are essentially vascular disorders.

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Mentioned in this Paper

Buffers
Gastric Ulcer
Mucositis
Structure of Pyloric Gland
Perfusion
Fragility
Fenilbutazon
Phenylbutazone
Vascular Diseases
Gastric Mucosa

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