Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards

AIDS Research and Human Retroviruses
Sonia Rodriguez-NóvoaVincent Soriano

Abstract

The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spaniards infected with HIV who received ABC treatment. The presence of HLA-B5701 had strong positive and negative predictive values for ABC HSR, 92% and 63%, respectively.

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Citations

Oct 16, 2008·Pharmacogenomics·Sonia Rodriguez-Nóvoa, Vincent Soriano
Jun 12, 2009·Critical Reviews in Clinical Laboratory Sciences·David Nolan
Jun 28, 2014·International Journal of Molecular Sciences·Tracy MasebeDebra Meyer
Mar 3, 2009·Medicina clínica·Bernardino Roca
Mar 5, 2014·Pharmacoepidemiology and Drug Safety·Tomoko KuritaYoshifumi Kitazono
May 3, 2015·The Journal of Allergy and Clinical Immunology·Bernardo Sousa-PintoLuís Delgado
Apr 17, 2012·International Journal of Hepatology·Manuela G NeumanCharles Parry
Jul 6, 2016·Frontiers in Pharmacology·Eng Wee Chua, Pei Yuen Ng
Oct 26, 2016·AIDS Research and Treatment·Jacinta Nwamaka NwoguBabafemi Taiwo
Jan 17, 2017·International Journal of Immunogenetics·G S GhattaorayaA Alfirevic
Jan 4, 2020·Allergy·Abderrahim OussalahUNKNOWN Task Force “Genetic predictors of drug hypersensitivity” of the European Network on Drug Allergy (ENDA), European Academy of

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