PMID: 43591Nov 3, 1979

Value of the meiosis test in male infertility

Schweizerische medizinische Wochenschrift
B LeibundgutD Da Rugna

Abstract

The histological evaluation of testicular biopsy in the investigation of infertility was supplemented by cytogenetic analysis of spermatogenesis in 72 patients from 1976--1978. The results show meiosis analysis to be a practical aid in the assessment of male infertility. It enables the point of interruption in the meiotic process to be accurately identified. A review of relative populations of meiotic and of interphase nuclei (the meiotic index) permits evaluation of a quantitative disturbance of spermatogenesis, a finding that is of particular value when establishing a patient's prognosis. Moreover, meiotic analysis makes it possible to recognize cytogenetic anomalies which could be responsible for the infertility state and which were chiefly seen in patients whose so-called primary infertility was hitherto classified as being of unknown origin. In two patients we thus identified a small additional chromosome in a fraction of the germinal cells, and also an abnormal pairing of all chromosomes, or the sex chromosomes alone, during the first meiotic division.

Related Concepts

Varicocele
Structure of Sertoli Cell
Testis
Spermatocytes
Subfertility, Male
Chromosome Aberrations
Spermiogenesis
M Phase, Meiotic
Biopsy
Unilateral Cryptorchidism

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