Value of the SYNTAX score for risk assessment in the all-comers population of the randomized multicenter LEADERS (Limus Eluted from A Durable versus ERodable Stent coating) trial

Journal of the American College of Cardiology
Joanna J WykrzykowskaPatrick W Serruys

Abstract

We aimed to assess the predictive value of the SYNTAX score (SXscore) for major adverse cardiac events in the all-comers population of the LEADERS (Limus Eluted from A Durable versus ERodable Stent coating) trial. The SXscore has been shown to be an effective predictor of clinical outcomes in patients with multivessel disease undergoing percutaneous coronary intervention. The SXscore was prospectively collected in 1,397 of the 1,707 patients enrolled in the LEADERS trial (patients after surgical revascularization were excluded). Post hoc analysis was performed by stratifying clinical outcomes at 1-year follow-up, according to 1 of 3 SXscore tertiles. The 1,397 patients were divided into tertiles based on the SXscore in the following fashion: SXscore<or=8 (SXlow) (n=464), SXscore>8 and <or=16 (SXmid) (n=472), and SXscore>16 (SXhigh) (n=461). At 1-year follow-up, there was a significantly lower number of patients with major cardiac event-free survival in the highest tertile of SXscore (SXlow=92.2%, SXmid=91.1%, and SXhigh=84.6%; p<0.001). Death occurred in 1.5% of SXlow patients, 2.1% of SXmid patients, and 5.6% of SXhigh patients (hazard ratio [HR]: 1.97, 95% confidence interval [CI]: 1.29 to 3.01; p=0.002). The myocardial infar...Continue Reading

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References

Mar 15, 2006·The New England Journal of Medicine·Marc A Pfeffer, John A Jarcho
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Nov 23, 2007·The New England Journal of Medicine·Rui WangJeffrey M Drazen
Jun 28, 2008·International Journal of Cardiology·William J van GaalAdrian P Banning
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators
Jul 7, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Patrick W SerruysFriedrich W Mohr

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Citations

Mar 23, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph SinningStefan Blankenberg
Nov 3, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Leslee J ShawDaniel S Berman
Jan 11, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Henry Gewirtz
Feb 9, 2013·Cardiovascular Intervention and Therapeutics·Hironori HaraKazuhiro Hara
Jun 8, 2011·Cardiology in Review·Ming-Sum Lee, David P Faxon
Dec 11, 2013·Clinical Interventions in Aging·Felipe José de Andrade FalcãoAntônio C Carvalho
Apr 27, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Scot GargUNKNOWN ARTS-II investigators
Jul 19, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tarek A N AhmedJ Wouter Jukema
Sep 21, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Joanna J WykrzykowskaPatrick W Serruys
Oct 27, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Joanna WykrzykowskaStephan Windecker
Mar 30, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Vasim FarooqPatrick W Serruys
Mar 30, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christopher J MalkinJulian Gunn
May 18, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Arthur KernerJonathan Lessick
Jun 2, 2011·Future Cardiology·Andrew J HoweIan B A Menown
Mar 8, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Bo XuUNKNOWN SEEDS Investigators
Jun 2, 2012·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Ron Waksman
Mar 20, 2012·The Canadian Journal of Cardiology·Anna Tomaszuk-KazberukWlodzimierz J Musial
Mar 28, 2016·The American Journal of Emergency Medicine·Oğuz KarahanCelal Yavuz
Oct 18, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Chris J MalkinJulian Gunn
Apr 19, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Philippe GarotMarie-Claude Morice
Apr 1, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Masahiro TakeshitaTetsuya Amano
Jan 11, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mayank YadavGregg W Stone
Feb 18, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Pascal VranckxStephan Windecker
Sep 21, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Kyung Woo ParkHyo-Soo Kim
Sep 10, 2011·Journal of the American College of Cardiology·Chang-Wook NamUNKNOWN FAME Study Investigators

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