PMID: 9447382Feb 3, 1998Paper

Value of thrombomodulin immunostaining in the diagnosis of transitional cell carcinoma: a comparative study with carcinoembryonic antigen

Histopathology
Nelson G Ordóñez

Abstract

Thrombomodulin (TM) is a surface glycoprotein involved in the regulation of intravascular coagulation that has been reported to be expressed in a variety of tumours. We investigated TM expression in transitional cell carcinoma (TCC) and compared the value of TM immunostaining with that of carcinoembryonic antigen (CEA) for differentiating TCC from other tumours with which it may be confused. Immunostaining was performed on formalin-fixed, paraffin-embedded tissue sections using the avidin-biotin-peroxidase complex method. TM immunoreactivity was observed in 80 of 91 primary (51/58 urinary bladder 10/12 renal pelvis, 3/3 ureter. 15/15 prostate, 1/3 ovary), and 18 of 20 metastatic TCCs expressed this marker. Only 37 of the 91 primary (23/58 urinary bladder, 4/12 renal pelvis, 1/3 ureter, 9/15 prostate, 0/3 ovary) and six of the 20 metastatic TCCs reacted for CEA. In order to evaluate the practical utility of TM immunostaining in surgical pathology, 30 adenocarcinomas of the prostate, 18 of the bladder, 12 of the colon, and 22 renal cell carcinomas were also stained for these markers. CEA reactivity was obtained in 12 of 30 adenocarcinomas of the prostate, 12 of 18 of the bladder, and 12 of 12 of the colon, but in none of the 22 r...Continue Reading

Citations

Nov 21, 1998·Histopathology·J Oxley, C Abbott
Aug 14, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rachele Del SordoAntonio Cavaliere
Jun 3, 2014·BMC Cancer·Chun-Te WuMiao-Fen Chen
Aug 14, 2012·Advances in Anatomic Pathology·Nelson G Ordóñez
Mar 13, 2012·Cancer Letters·Mario MenschikowskiGabriele Siegert
Mar 4, 2006·Seminars in Diagnostic Pathology·Robert E Emerson, Thomas M Ulbright
May 2, 2001·Human Pathology·K T MaiR Gerridzen
Jun 10, 2005·Journal of Biochemistry·Shingo NiimiTakao Hayakawa
May 25, 2002·Journal of Cutaneous Pathology·Pratistadevi K RamdialShivon M Singh
Apr 12, 2003·Journal of Cutaneous Pathology·Simin MeymandiRichard I Crawford
May 21, 2020·Research and Reports in Urology·Joanne WattMark W Ruddock
Mar 29, 2000·The Annals of Otology, Rhinology, and Laryngology·J M HansonS K El-Mofty
Nov 28, 2002·Human Pathology·Paulette MhawechMarie-Françoise Pelte
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Armita BahramiJae Y Ro

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