PMID: 8945070Nov 1, 1996Paper

Value of time- and frequency-domain analysis of signal-averaged electrocardiography for arrhythmia risk prediction in idiopathic dilated cardiomyopathy

Pacing and Clinical Electrophysiology : PACE
W GrimmB Maisch

Abstract

Signal-averaged electrocardiography (SAECG) was performed in 120 consecutive patients with idiopathic dilated cardiomyopathy (IDC), and in 60 healthy controls. Time-domain analysis of SAECGs revealed ventricular late potentials in 27 of 120 patients with IDC (23%) compared to 2 of 60 controls (3%; P < 0.05). Frequency-domain analysis of SAECGs showed ventricular late potentials in 9 of 120 patients with IDC (8%) compared to none of the 60 controls (0%, P < 0.05). During a prospective follow-up of 15 +/- 7 months, serious arrhythmic events, defined as sustained ventricular tachyarrhythmias or sudden death, occurred in 17 of 120 patients with IDC (14%). The sensitivity, specificity, and positive and negative predictive values of ventricular late potentials for serious arrhythmic events were 35%, 80%, 22%, and 88% for the time-domain analysis, and 18%, 94%, 33%, and 87% for the frequency-domain analysis of SAECG, respectively. Thus, neither the time-nor the frequency-domain analysis of SAECG appears to be useful for risk stratification in the setting of IDC in view of their low sensitivity and low positive predictive value for serious arrhythmic events during follow-up.

References

Jun 1, 1988·The American Journal of Cardiology·T A BuckinghamH L Kennedy

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Citations

Dec 7, 2002·International Journal of Cardiology·Maciej KarczWitold Ruzyłło
Jan 15, 2002·Journal of the American College of Cardiology·Hidetsuna KitamuraMitsuhiro Yokoyama
Aug 10, 1999·Journal of the American College of Cardiology·K AdachiM Yokoyama
Feb 1, 2003·Japanese Heart Journal·Katsunori OkajimaMitsuhiro Yokoyama
Mar 31, 2007·American Heart Journal·S Luke Kusmirek, Michael R Gold
Aug 2, 2005·International Journal of Cardiology·Majid HaghjooMohammad Ali Sadr-Ameli
Jul 10, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Wolfram GrimmHans-Helge Müller
Nov 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Hidetsuna KitamuraMitsuhiro Yokoyama

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