Abstract
Aplastic anemia is a rare, serious blood disorder due to bone marrow failure to produce blood cells. Transfusions are used to reduce risk of bleeding, infection and relieve anemia symptoms. In severe patients, transfusions may be required more than once/week. It is unclear from the patient perspective the impact that transfusions have on quality of life. This study aimed to elicit patient preferences for attributes associated with severe aplastic anemia (SAA) treatment, including transfusion independence. An online discrete choice experiment (DCE) was conducted among patients with SAA who experienced insufficient response to immunosuppressive therapy and transfusion dependence for ≥3 months in the past 2 years. Recruitment occurred through the Aplastic Anemia and Myelodysplastic Syndromes International Foundation and referrals from clinical sites in the US and France. Respondents chose between hypothetical treatment pairs characterized by a common set of attributes: transfusions frequency, fatigue, risk of infection, and risk of serious bleeding. Conditional logit model with effects coding was used to estimate part-worth utilities for different attribute levels and the relative importance of each attribute. Predicted utility sc...Continue Reading
References
Nov 26, 1999·Leukemia Research·P GuptaV A Morrison
Jul 2, 2003·Cancer·Harrys A TorresDimitrios P Kontoyiannis
Jun 24, 2005·Cancer·Christina A MeyersElihu Estey
Apr 12, 2006·Cancer·Lodovico Balducci
Mar 30, 2007·European Journal of Haematology·Masaaki TakatokuUNKNOWN Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes
Dec 7, 2007·Leukemia Research·David P SteensmaRuben A Mesa
Jun 25, 2009·Seminars in Hematology·Jessica M ValdezThomas J Walsh
Sep 10, 2009·Health and Quality of Life Outcomes·Agota SzendeAlan F List
Mar 17, 2010·Transfusion·Esther Natalie OlivaFrancesco Nobile
Jan 5, 2012·BMC Health Services Research·Nasir UmarDarcey D Terris
Apr 11, 2012·Transfusion·Stuart L GoldbergMarianne Laouri
Apr 17, 2012·Arthritis Care & Research·Heather F BurnettWendy J Ungar
Apr 21, 2012·Blood·Phillip Scheinberg, Neal S Young
Jan 23, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·F Reed JohnsonJohn F P Bridges
May 22, 2013·International Journal of Hematology·Danielle M TownsleyNeal S Young
Sep 21, 2013·Blood·Judith C W Marsh, Austin G Kulasekararaj
Dec 19, 2013·Blood·Ronan DesmondCynthia E Dunbar
Mar 1, 2014·Cancer·David P SteensmaMikkael A Sekeres
Nov 29, 2014·International Journal of Hematology·Peng JinYizhou Zheng
May 21, 2015·Rheumatology·Mark HarrisonNick Bansback
Nov 17, 2015·British Journal of Haematology·Sally B KillickUNKNOWN British Society for Standards in Haematology
Mar 20, 2016·Applied Health Economics and Health Policy·Axel Mühlbacher, F Reed Johnson
Mar 24, 2016·Therapeutic Advances in Neurological Disorders·Christine PoulosBernd Kieseier
May 20, 2016·Anemia·Ioannis Koutsavlis
Jun 22, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·A Brett HauberJohn F P Bridges