Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study

Annals of the Rheumatic Diseases
Maria-Antonietta d'AgostinoOMERACT-EULAR-Ultrasound Task Force

Abstract

To study the responsiveness of a combined power Doppler and greyscale ultrasound (PDUS) score for assessing synovitis in biologic-naïve patients with rheumatoid arthritis (RA) starting abatacept plus methotrexate (MTX). In this open-label, multicentre, single-arm study, patients with RA (MTX inadequate responders) received intravenous abatacept (∼10 mg/kg) plus MTX for 24 weeks. A composite PDUS synovitis score, developed by the Outcome Measures in Rheumatology-European League Against Rheumatism (OMERACT-EULAR)-Ultrasound Task Force, was used to evaluate individual joints. The maximal score of each joint was added into a Global OMERACT-EULAR Synovitis Score (GLOESS) for bilateral metacarpophalangeal joints (MCPs) 2-5 (primary objective). The value of GLOESS containing other joint sets was explored, along with clinical efficacy. Eighty-nine patients completed the 24-week treatment period. The earliest PDUS sign of improvement in synovitis was at week 1 (mean change in GLOESS (MCPs 2-5): -0.7 (95% CIs -1.2 to -0.1)), with continuous improvement to week 24. Early improvement was observed in the component scores (power Doppler signal at week 1, synovial hyperplasia at week 2, joint effusion at week 4). Comparable changes were obser...Continue Reading

References

Mar 8, 2005·Arthritis and Rheumatism·Mikkel Østergaard, Marcin Szkudlarek
Jun 4, 2005·Australasian Radiology·F JoshuaM Lassere
Jun 9, 2005·Best Practice & Research. Clinical Rheumatology·Walter GrassiEmilio Filippucci
Apr 3, 2008·Arthritis and Rheumatism·Esperanza NaredoUNKNOWN Ultrasound Group of The Spanish Society of Rheumatology
Jan 19, 2012·Rheumatology·Ahmed S ZayatRichard J Wakefield

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Citations

May 29, 2016·Pediatric Rheumatology Online Journal·Silvia Magni-Manzoni
Aug 17, 2016·Sports Health·O Kenechi Nwawka
Nov 29, 2017·Clinical Rheumatology·Merve Ozata OlmezSibel Zehra Aydin
Apr 14, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·George PentazosElias Siores
Feb 6, 2017·The Journal of Rheumatology·Lene TerslevUNKNOWN OMERACT Ultrasound Group
Sep 14, 2019·World Journal of Pediatrics : WJP·Li-Xia ZouLawrence Kwok Leung Jung
Jun 21, 2020·Current Rheumatology Reports·Andrea Di MatteoRichard J Wakefield
Jun 12, 2020·Therapeutic Advances in Musculoskeletal Disease·Kenneth F BakerJohn D Isaacs
Oct 4, 2017·International Journal of Rheumatic Diseases·John C AllenYork Kiat Tan
Apr 24, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Gaël MouterdeMaria-Antonietta D'Agostino

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Methods Mentioned

BETA
PCA

Clinical Trials Mentioned

NCT00767325

Software Mentioned

PDUS
GLOESS

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