Valve-in-valve implantation using a novel supravalvular transcatheter aortic valve: proof of concept.

The Annals of Thoracic Surgery
Ali N AzadaniElaine E Tseng

Abstract

Transcatheter valve implantation within degenerated bioprostheses is a potentially promising treatment for high-risk surgical patients. Clinical experience is limited; however, we have shown in vitro that currently available transcatheter aortic valve sizes did not provide acceptable hemodynamics in small bioprostheses. The objective of this study was to develop a new transcatheter valve that would provide good hemodynamics within degenerated bioprostheses. Supravalvular transcatheter valves were created using a Dacron covered stainless steel stent at the base and trileaflet pericardial leaflets in an open stent above the bioprosthesis. The transcatheter valves were implanted within 19-, 21-, and 23-mm Carpentier-Edwards Perimount bioprostheses with simulated degeneration using BioGlue to achieve a mean pressure gradient of 50 mm Hg. Hemodynamics of valve-in-valve implantation were studied in a pulse duplicator. Supravalvular transcatheter valves successfully relieved bioprosthetic stenosis. Acceptable hemodynamics were achieved with a significant reduction in mean pressure gradient of 54.0 +/- 3.5 to 9.2 +/- 6.3 mm Hg in 23-mm bioprostheses (p < 0.001), from 49.3 +/- 3.1 to 14.4 +/- 4.7 mmHg (p < 0.001) in 21 mm, and from 53.9...Continue Reading

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Citations

Apr 17, 2010·Interactive Cardiovascular and Thoracic Surgery·Ali N AzadaniElaine E Tseng
Dec 15, 2010·Future Cardiology·Ali N Azadani, Elaine E Tseng
Sep 18, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Darren MylotteNicolo Piazza
Jul 12, 2013·ISRN Cardiology·Siyamek Neragi-Miandoab, Robert E Michler
Dec 3, 2015·JACC. Cardiovascular Interventions·Prem A MidhaAjit P Yoganathan
Dec 16, 2011·The Journal of Thoracic and Cardiovascular Surgery·Moritz SeiffertHendrik Treede
Jun 28, 2011·The Annals of Thoracic Surgery·Ali N AzadaniElaine E Tseng
Jun 30, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuki MorimotoTomoyuki Fujita
Sep 5, 2015·Journal of Biomechanics·Mostafa Abbasi, Ali N Azadani
Nov 26, 2009·The Annals of Thoracic Surgery·Thomas Walther, Claudia Walther
Nov 15, 2011·Journal of the American College of Cardiology·Ronen GurvitchJohn G Webb
May 18, 2016·The Journal of Thoracic and Cardiovascular Surgery·Stephane Leung Wai SangPrashanth Vallabhajosyula
May 1, 2016·The Journal of Thoracic and Cardiovascular Surgery·Elaine E Tseng
Aug 6, 2016·JACC. Cardiovascular Interventions·Prem A MidhaAjit P Yoganathan
Sep 13, 2016·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Yoshimasa SakamotoKazuhiro Hashimoto
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Jan 20, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Koohyar VahidkhahAli N Azadani
Dec 12, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jayendrakumar S PatelSamir R Kapadia
Aug 31, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Danny DvirDarren Mylotte
Jul 10, 2018·Journal of the American Heart Association·Anupama ShivarajuAlbert M Kasel
Dec 22, 2011·Circulation. Cardiovascular Interventions·Ali N Azadani, Elaine E Tseng
Oct 16, 2018·Expert Review of Medical Devices·Oren M RotmanDanny Bluestein
Jun 24, 2015·Annals of Biomedical Engineering·Barry J Doyle, Paul E Norman
Nov 28, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Janarthanan SathananthanJohn G Webb
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