Valvular manifestations of human immunodeficiency virus infection--results from the prospective, multicenter HIV-HEART study

Journal of Cardiovascular Medicine
Nico ReinschTill Neumann

Abstract

HIV infection is associated with an elevated rate of cardiac diseases. The aim of the current study was to assess the prevalence of valvular disorders in a large population of HIV-infected patients. We enrolled 803 adults (age 44 ± 10 years, 16.6% women) in this prospective, multicenter cohort study. All patients underwent a comprehensive two-dimensional transthoracic echocardiography examination including Doppler evaluation of valvular function. Statistical analyses were performed in respect of severity of HIV infection. Overall, the rate of patients with pathologic function of cardiac valves was 77.6% (N = 623). Most of these patients had signs of valvular regurgitation (N = 620; 77.2%), whereas stenoses were rare (N = 23; 2.9%). Clinically relevant valvular disorders (excluding mild stages) were seen in only 4.7% (N = 38; regurgitation: N = 36, 4.5%; stenosis: N = 3, 0.4%). Clinical stages of HIV infection, defined by the Centers for Disease Control and Prevention (CDC) classification, were associated with higher rates of valvular diseases (CDC-stage B/C versus A: 6.2 versus 2.3%, P = 0.015). However, there was no association between current CD4 cell count or virus load and the prevalence of valvular disorders (both P > 0.2)...Continue Reading

References

Jan 1, 1990·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A L KleinJ B Seward
Oct 13, 1998·Journal of the American College of Cardiology·M J GarciaA L Klein
Jul 20, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Qingyi MengShenghan Lai
Sep 11, 2002·Circulation·Giuseppe Barbaro
Dec 14, 2002·Lancet·Scott D HolmbergUNKNOWN HIV Outpatient Study (HOPS) investigators
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
Sep 16, 2004·The American Journal of the Medical Sciences·Dustin T SmithUNKNOWN Emory Endocarditis Group
Sep 29, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·John S GottdienerUNKNOWN American Society of Echocardiography
Nov 18, 2004·Echocardiography·Dustin P Letts, Angel López-Candales
Jan 7, 2005·The New England Journal of Medicine·Steven Grinspoon, Andrew Carr
Dec 1, 2006·The New England Journal of Medicine·UNKNOWN Strategies for Management of Antiretroviral Therapy (SMART) Study GroupC Rappoport
Feb 22, 2007·Journal of Cardiovascular Medicine·Enrico CecchiRita Trinchero
Apr 27, 2007·The New England Journal of Medicine·UNKNOWN DAD Study GroupJens D Lundgren
Apr 9, 2008·The American Journal of Cardiology·Iris SchusterPhilippe Obert
Sep 2, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki OkuraKiyoshi Yoshida

❮ Previous
Next ❯

Citations

Aug 1, 2015·Emergency Medicine Clinics of North America·Thuy Van Pham, Mercedes Torres
Aug 3, 2020·Current Cardiology Reports·Karan Sud, Edgar Argulian
Mar 14, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ahmed AljizeeriMouaz H Al-Mallah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved