PMID: 11311936Apr 20, 2001Paper

VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain

Biochimica Et Biophysica Acta
T C TsengA H Chishti

Abstract

The MAGUKs (membrane-associated guanylate kinase homologues) constitute a family of peripheral membrane proteins that function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. Here, we report the characterization of the human vam-1 gene that encodes a novel member of the p55 subfamily of MAGUKs. The complete cDNA sequence of VAM-1, tissue distribution of its mRNA, genomic structure, chromosomal localization, and Veli-1 binding properties are presented. The vam-1 gene is composed of 12 exons and spans approx. 115 kb. By fluorescence in situ hybridization the vam-1 gene was localized to 7p15-21, a chromosome region frequently disrupted in some human cancers. VAM-1 mRNA was abundant in human testis, brain, and kidney with lower levels detectable in other tissues. The primary structure of VAM-1, predicted from cDNA sequencing, consists of 540 amino acids including a single PDZ domain near the N-terminus, a central SH3 domain, and a C-terminal GUK (guanylate kinase-like) domain. Sequence alignment, heterologous transfection, GST pull-down experiments, and blot overlay assays revealed a conserved domain in VAM-1 ...Continue Reading

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Citations

Apr 29, 2005·Brain Research. Molecular Brain Research·Zhang Jing-PingTatsuo Suzuki
Sep 24, 2008·Protein Science : a Publication of the Protein Society·Ingo PaarmannManfred Konrad
Dec 5, 2008·Traffic·Silvia MassariGrazia Pietrini
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Jul 6, 2004·Molecular Reproduction and Development·Heather R BurkinDavid J Miller
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Jun 17, 2003·The Journal of Biological Chemistry·Toshihiko HanadaAthar H Chishti
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Aug 15, 2019·Histochemistry and Cell Biology·Akio KamijoNobuo Terada
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka ChytłaAleksander Czogalla

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