Van Wyk Grumbach Syndrome: A Rare Consequence of Hypothyroidism

Indian Journal of Pediatrics
Pavan ReddyRaju Khubchandani

Abstract

Long standing hypothyroidism presenting as an ovarian mass has been well described in literature as the Van Wyk Grumbach syndrome (hypothyroidism, isosexual precocious puberty and ovarian mass). Here, authors report this entity in a 11 y 7 mo old girl child who was referred to a surgeon in view of intestinal obstruction along with a multiloculated ovarian cyst. On evaluation, she was found to have raised serum creatinine, short stature, delayed bone age and pituitary enlargement. She was diagnosed with autoimmune thyroiditis and was started on replacement therapy with thyroxine, after which the ovarian cysts regressed. This entity should be kept in mind in cases of ovarian cysts, especially those with isosexual precocity, to prevent unnecessary evaluation and surgical misadventures.

References

Jun 1, 1996·Archives of Pediatrics & Adolescent Medicine·M P DesaiM P Colaco
Oct 24, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Aravind Raj SanjeevaiahSri S Srikanta
Feb 4, 1905·British Medical Journal·F W Kendle
Oct 4, 2011·Indian Journal of Endocrinology and Metabolism·Ashu RastogiAnil Bhansali

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Citations

Jul 4, 2020·Annals of Pediatric Endocrinology & Metabolism·Su-Jeong LeeCheol Woo Ko
Jun 2, 2020·Journal of Obstetrics and Gynaecology of India·S KrishnakumarRohan Krishnakumar
Oct 22, 2020·Indian Journal of Endocrinology and Metabolism·Moutusi Raychaudhuri, Debmalya Sanyal
Nov 23, 2020·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Natalie GuerreroMeghna R Sebastian

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Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

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