PMID: 7011382Dec 11, 1980Paper

Vanadate enhances the stimulatory action of insulin on DNA synthesis in cultured mouse mammary gland

Biochimica Et Biophysica Acta
C Hori, T Oka

Abstract

In order to assess the importance of ions in the regulation of mammary epithelial cell proliferation, the effect of various polyvalent ions was examined on insulin- and lithium-ion-dependent DNA synthesis in mouse mammary gland from virgin mice cultured in a serum-free, chemically defined medium. Addition of 2 to 10 microM orthovanadate enhanced the stimulatory effect of insulin on DNA synthesis in cultured tissue. Similar results were obtained with metavanadate. In contrast, vanadate did not augment Li+-stimulated DNA synthesis but rather inhibited this process. Vanadate by itself caused only a slight stimulation of DNA synthesis. These results indicate that vanadate acts as a co-mitogen in insulin-stimulated DNA synthesis in cultured mammary cells and suggest that the mitogenic action of insulin involves an ion-dependent path which may be common to the actions of vanadate and lithium ion.

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Citations

Dec 6, 1995·Molecular and Cellular Biochemistry·H Wang, R E Scott
Dec 6, 1995·Molecular and Cellular Biochemistry·A B GoldfineC R Kahn
Feb 1, 1994·Mutation Research·A Léonard, G B Gerber
May 3, 2003·Free Radical Biology & Medicine·Zhuo ZhangXianglin Shi
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J B Smith
Mar 1, 1989·Environmental Health Perspectives·F Borellini, T Oka
Mar 1, 1987·International Journal of Cell Cloning·U HanauskeD D Von Hoff
Jan 1, 1990·Archives of Biochemistry and Biophysics·G L MendzP W Kuchel
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E Gallo-HendrikxZ X Xiao
May 23, 2003·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Daniel A BarrioSusana B Etcheverry
Nov 15, 2000·Canadian Journal of Physiology and Pharmacology·M C CamJ H McNeill
Jul 22, 1982·Biochimica Et Biophysica Acta·H ZemkováF Vyskocil
Jul 1, 1983·Molecular and Cellular Endocrinology·G Carpenter
Jan 30, 1984·Biochemical and Biophysical Research Communications·D CasselL Glaser
Oct 30, 1981·Biochemical and Biophysical Research Communications·G Carpenter
Aug 31, 1987·Biochemical and Biophysical Research Communications·S KadotaB I Posner

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