PMID: 9161814Feb 1, 1997Paper

Vanadium-mediated chemoprotection against chemical hepatocarcinogenesis in rats: haematological and histological characteristics

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
A BishayeeM Chatterjee

Abstract

The trace element vanadium was investigated for its anti-neoplastic role in relation to haematological status, hepatic histopathology and histochemical analysis of glycogen in liver. Its impact on the survival of male Sprague-Dawley rats subjected to a two-stage hepatocarcinogenesis regimen was also assessed. Initiation was performed using a single intraperitoneal injection of diethylnitrosamine (DENA) (200 mg/kg) followed by promotion with phenobarbital (0.05%) in a basal diet. Vanadium supplementation as ammonium monovanadate at 0.5 ppm vanadium in drinking water was given ad libitum throughout the experiment (20 weeks), before the initiation (4 weeks), or during the promotional period (14 weeks). At the end of the study, there was a significant decrease in red blood cell count, haemoglobin content, haematocrit value, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, plasma volume change and total white cell count, with a concurrent alteration in lymphoid:myeloid ratio in DENA control animals compared with their normal counterparts. Vanadium supplementation throughout the study or before the initiation significantly reversed the DENA-induced alterations in most of the haematological indices. A single i...Continue Reading

Citations

Sep 21, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Elizabeth E Hamilton, Jonathan J Wilker
Jan 21, 2000·Free Radical Biology & Medicine·W Bors, C Michel
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