PMID: 2484412Dec 1, 1989Paper

Vanadium transport across placenta and milk of rats to the fetus and newborn

Biological Trace Element Research
J Edel, E Sabbioni

Abstract

The transport of vanadium across placenta and milk rats was studied by iv injection of low doses of 48V-labeled pentavanadate (0.1 micrograms V/rat) to pregnant and nursing rats. Significant concentrations of vanadium were found in the liver, intestine, and kidneys of the fetuses, showing that vanadium is capable to pass the placental barrier and, thus, being metabolized in the fetuses. Two days after injection of 0.1 micrograms V/rat as 48V-labeled vanadate to nursing rats, 34 ng V/g milk were found, decreasing to 4 ng V/g at the d 12 after dosing. The corresponding suckling rats showed a significant absorption of vanadium taken up by the milk, as suggested by the presence in their intestine, where 48V is easily absorbed in form of low molecular weight components. Vanadium in milk may be transported in the form of a biocomplex with lactoferrin, since at 12 d after injection, the 48V in the rat milk was mainly found in fractions corresponding to proteins. In weanling rats, 7 d postlactation and 18 d after administration of vanadium to the mother, only very small amounts of 48V were still present in the organs. Excretion studies on weanling rats for 7 d showed that vanadium is rapidly released mainly via feces when earlier taken...Continue Reading

References

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Citations

Sep 1, 1991·Biological Trace Element Research·D SanchezJ Corbella
Mar 12, 2010·Cell Biology and Toxicology·Ghada AbdelhamidAyman O S El-Kadi
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Zaporowska, W Wasilewski
Jun 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Zaporowska, W Wasilewski
Sep 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Zaporowska, W Wasilewski
May 1, 1996·Reproductive Toxicology·J L Domingo
Mar 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·E RussanovS Konstantinova
Jan 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ashraf M Morgan, Osama S El-Tawil
Sep 1, 1992·Journal of Toxicology and Environmental Health·M GómezJ Corbella
Apr 6, 2013·Neurotoxicology and Teratology·Santiago CuestaGraciela Beatriz García
Jun 14, 2014·Environmental Toxicology and Pharmacology·Oluwaseun MustaphaJames Olopade
Jul 6, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ghada AbdelhamidAyman O S El-Kadi
May 12, 2007·Neurotoxicology and Teratology·Marina Soazo, Graciela Beatriz Garcia
Apr 7, 2015·Journal of Inorganic Biochemistry·Andrew J GhioMitchell D Cohen
Jun 11, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anwar Anwar-Mohamed, Ayman O S El-Kadi
Aug 11, 2017·Environmental Science & Technology·Ted OzerskyMarianne V Moore

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