Vancomycin- and Strontium-Loaded Microspheres with Multifunctional Activities against Bacteria, in Angiogenesis, and in Osteogenesis for Enhancing Infected Bone Regeneration

ACS Applied Materials & Interfaces
Pengfei WeiXiaoping Yang

Abstract

Biomaterials that have capacities to simultaneously induce bone regeneration and kill bacteria are in demand because bone defects face risks of severe infection in clinical therapy. To meet the demand, multifunctional biodegradable microspheres are fabricated, which contain vancomycin to provide antibacterial activity and strontium-doped apatite to provide osteocompatibility. Moreover, the strontium component shows activity in promoting angiogenesis, which further favors osteogenesis. For producing the microspheres, vancomycin is loaded into mesoporous silica and embedded in polylactide-based microspheres via the double emulsion technique and the strontium-doped apatite is deposited onto the microspheres via biomineralization in strontium-containing simulated body fluid. Sustained release behaviors of both vancomycin and Sr2+ ions are achieved. The microspheres exhibit strong antibacterial effect against Staphylococcus aureus, while demonstrating excellent cell/tissue compatibility. Studies of differentiation confirm that the introduction of strontium element strengthens the angiogenic and osteogenic expressions of mesenchymal stromal cells. Subcutaneous injection of the microspheres into rabbit's back confirms their effectiven...Continue Reading

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Citations

Sep 24, 2020·Journal of Biomaterials Science. Polymer Edition·Jianping MaoQing Cai
Jul 3, 2020·Frontiers in Bioengineering and Biotechnology·Giulia MontagnaLouis Gerstenfeld
Oct 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianyi ZhengXiaoping Yang
Jan 24, 2021·Carbohydrate Polymers·Rabyya KausarIhsan Ul-Haq
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xintao ZhangHui Zeng
Mar 2, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tao SongXingdong Zhang
Mar 30, 2021·Bio-medical Materials and Engineering·Mario Pérez SayansPía López Jornet
Apr 29, 2021·International Journal of Nanomedicine·Xingfang YuHongwei Chen

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