Vancomycin enhancement of experimental tobramycin nephrotoxicity.

Antimicrobial Agents and Chemotherapy
C A WoodD N Gilbert

Abstract

The influence of vancomycin on tobramycin nephrotoxicity was assessed in male Fischer rats. Treatment groups included controls receiving diluent and groups receiving vancomycin alone at a dosage of 200 mg/kg (body weight) per day, tobramycin alone at a dosage of 80 mg/kg per day, and a combination of vancomycin and tobramycin at the above dosages. All regimens were injected on a twice-a-day schedule. The animals were sacrificed on days 1, 3, 10, 14, 17, and 21. When compared with controls, animals receiving vancomycin alone exhibited no detectable renal toxicity. Compared with the case with controls, tobramycin alone was toxic, as manifested by lower mean animal weights, increased blood urea nitrogen concentrations on days 14 and 17 (P less than 0.005), increased serum creatinine concentrations on days 17 and 21 (P less than 0.005), and the presence of renal cortical tubular necrosis and regeneration. When compared with tobramycin alone, the combination of vancomycin and tobramycin caused earlier and more severe toxicity. By day 10, the magnitude of weight loss, the rise in blood urea nitrogen, and the increase in serum creatinine concentration were all greater in the rats given the combination of vancomycin plus tobramycin tha...Continue Reading

References

Mar 31, 1977·The New England Journal of Medicine·G B Appel, H C Neu
Mar 24, 1977·The New England Journal of Medicine·G B Appel, H C Neu
Jan 1, 1978·Antimicrobial Agents and Chemotherapy·D N GilbertG Porter
Aug 1, 1985·The Journal of Antimicrobial Chemotherapy·T C Sorrell, P J Collignon
Jun 1, 1985·The Journal of Antimicrobial Chemotherapy·J A MellorC T Keane
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·B F Farber, R C Moellering
Dec 1, 1984·The Journal of Antimicrobial Chemotherapy·R S Griffith
Feb 1, 1984·The American Journal of Medicine·J HerzsteinV T Andriole
Sep 1, 1984·The Journal of Antimicrobial Chemotherapy·R MarreK Sack
Nov 1, 1981·Reviews of Infectious Diseases·J S Wold, S A Turnipseed
Feb 1, 1981·Antimicrobial Agents and Chemotherapy·G R AronoffF C Luft
Aug 1, 1961·Annals of Internal Medicine·D W WOODLEY, W H HALL

❮ Previous
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Citations

Nov 1, 1993·Head & Neck·R C McGlennenR S Ostrow
Jul 1, 1991·Journal of Clinical Pharmacology·M Y MunarW M Bennett
May 1, 1990·Toxicology Letters·S Kacew, M G Bergeron
Jun 1, 1994·The Annals of Pharmacotherapy·R D Bates, M C Nahata
Aug 26, 1998·International Journal of Antimicrobial Agents·A P Wilson
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J Rybak
Jul 1, 1992·Pharmacology & Toxicology·B FauconneauA Piriou
Oct 1, 1987·Antimicrobial Agents and Chemotherapy·M J RybakL M Albrecht
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·E WolinskyM D Iseman
Jun 1, 1989·Antimicrobial Agents and Chemotherapy·R E Brummett, K E Fox
Aug 1, 1989·Antimicrobial Agents and Chemotherapy·C A WoodD N Gilbert
Sep 1, 1989·Antimicrobial Agents and Chemotherapy·M NgelekaM G Bergeron
Jan 1, 1990·Antimicrobial Agents and Chemotherapy·D BeauchampM G Bergeron
Oct 1, 1991·Antimicrobial Agents and Chemotherapy·D E NixJ J Schentag
Feb 1, 1994·Antimicrobial Agents and Chemotherapy·D BeauchampM G Bergeron
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·D BeauchampM G Bergeron
May 9, 2002·Biological & Pharmaceutical Bulletin·Tomoko YazakiMotoko Kanke
May 14, 2004·Clinical Pharmacokinetics·Matthijs de HoogJohn N van den Anker
Mar 22, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Riitta OjalaOuti Tammela
Nov 1, 1994·Intensive Care Medicine·A W Chow, R M Azar
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·D Beauchamp, M Pettigrew
Apr 14, 2006·Expert Opinion on Drug Safety·Joshua G YorgasonFederico Kalinec
Oct 21, 2005·Basic & Clinical Pharmacology & Toxicology·Ilhami CelikH Handan Akbulut
Dec 7, 2010·International Journal of Antimicrobial Agents·Annie Wong-BeringerPaul Beringer
Nov 30, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Abhisekh Sinha RayAlan S L Yu
May 6, 2017·Clinical Pharmacology and Therapeutics·E J FilipponeJ L Farber
Oct 8, 2013·Toxicology and Industrial Health·Ahmet KoyuMustafa Saygin
Jun 14, 2016·Therapeutic Advances in Endocrinology and Metabolism·Oluwatoyin Bamgbola
Feb 10, 2016·Antimicrobial Agents and Chemotherapy·Rocío ÁlvarezJerónimo Pachón
Oct 3, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stefanie M ShielsJoseph C Wenke
Dec 25, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael RybakDonald P Levine
Nov 2, 2019·Journal of Nutritional Science and Vitaminology·Masaki TakigawaAkihito Ishigami
Apr 1, 1996·Therapeutic Drug Monitoring·L PouC Pascual
Feb 20, 2016·Current Opinion in Infectious Diseases·Jodi M LestnerMike Sharland
Apr 1, 1989·DICP : the Annals of Pharmacotherapy·M E BurtonM R Vasko
May 31, 2006·Molecular and Cellular Biochemistry·Mehmet SahinH Ramazan Yilmaz

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