Vancomycin-induced Immune Thrombocytopenia Proven by the Detection of Vancomycin-dependent Anti-platelet Antibody with Flow Cytometry

Internal Medicine
Jun YamanouchiMasaki Yasukawa

Abstract

Vancomycin-induced thrombocytopenia is a rare adverse reaction that may be overlooked because no specific diagnostic test is currently available. We herein report a patient with vancomycin-induced immune thrombocytopenia who was diagnosed by the detection of vancomycin-dependent anti-platelet antibody with flow cytometry. An IgG antibody in the patient's serum reacted with platelets only in the presence of vancomycin. Severe thrombocytopenia gave rise to life-threatening gastrointestinal bleeding, which was quickly resolved after effective platelet transfusion following the cessation of vancomycin administration. This report suggests that the flow cytometric test is useful for the differential diagnosis of thrombocytopenia and platelet transfusion should be performed after the cessation of vancomycin administration.

References

Jan 1, 1997·Vox Sanguinis·P MizonJ Goudemand
Mar 11, 1999·American Journal of Hematology·J C KuruppuC U Tuazon
Oct 6, 1999·American Journal of Hematology·R GovindarajanC Zent
Oct 4, 2003·Pharmacotherapy·Jeanna MarraffaSyed Nazeer
Mar 16, 2005·Toxicology·Richard H Aster
Mar 3, 2007·The New England Journal of Medicine·Theodore E Warkentin
Mar 3, 2007·The New England Journal of Medicine·Annette Von DrygalskiRichard H Aster
Oct 16, 2009·Journal of Medical Case Reports·Ravish A ShahNancy Khardori
Dec 14, 2011·Clinical Pharmacokinetics·Amélie MarsotNicolas Simon
Sep 16, 2014·Pharmacotherapy·Joseph J CarrenoBen Lomaestro
Nov 18, 2014·Frontiers in Public Health·Ethan Rubinstein, Yoav Keynan
Mar 31, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Marco FalconeMario Venditti
Oct 1, 2012·Clinical Pharmacology in Drug Development·Amélie MarsotNicolas Simon

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Citations

Apr 30, 2020·Arthroplasty Today·Ian Savage-ElliottFernando L Sanchez
Mar 18, 2021·World Journal of Clinical Cases·Si-Ri GulengXiao-Bin Guo
Sep 19, 2021·Seminars in Dialysis·Ahmet MurtMuveddet Rezzan Ataman

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Methods Mentioned

BETA
flow cytometry
ELISA

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