PMID: 8594637Jan 1, 1995Paper

Vancomycin levels after intravitreal injection. Effects of inflammation and surgery

Retina
H E AguilarM K Neisman

Abstract

Vancomycin hydrochloride for intraocular injection is the drug of choice for the treatment of suspected gram-positive endophthalmitis. To study its intraocular pharmacokinetics, we injected vancomycin into the vitreous cavity of phakic, aphakic, and aphakic-vitrectomized rabbit eyes and determined its rate of clearance. Inflamed eyes were compared to control eyes in each group. Three groups of eyes were prepared. The eyes in Group 1 were phakic, the eyes in Group 2 had the lens removed, and the eyes in Group 3 had both the lens and central vitreous removed. Each group was subdivided into a control group and a group made inflamed by injection of heat-killed Staphylococcus epidermidis. Vancomycin hydrochloride 1 mg in 0.1 cc of diluent was injected into the midvitreous cavity and samples obtained at 2 or 3, 8, 24, and 48 hours after injection. Vancomycin concentrations were measured and clearance rates were calculated for each of the groups. Vancomycin was cleared substantially faster from aphakic-vitrectomized eyes (half-life 9.0 hours) and aphakic eyes (half-life 8.9 hours) than phakic eyes (half-life 25.1 hours). Inflammation increased the rate of elimination of vancomycin only in the aphakic group. Clearance of vancomycin fro...Continue Reading

Citations

Oct 22, 2002·Journal of Cataract and Refractive Surgery·Klaus D Teichmann
Jul 11, 2007·Retina·Craig A Lemley, Dennis P Han
Oct 24, 2001·The British Journal of Ophthalmology·I M GanJ C van Meurs
Feb 22, 2012·The Journal of Antimicrobial Chemotherapy·Traci Nicole FraserDaniel M Musher
Feb 21, 2016·American Journal of Ophthalmology·Jack D StringhamJames T Banta
Apr 4, 2013·Current Eye Research·John B ChristoforidisZhongfa Liu
Feb 4, 2006·Drug and Chemical Toxicology·Murat SonmezOguz Gulecek
Jan 21, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eva M del AmoArto Urtti
Feb 27, 2010·Journal of Biomedical Materials Research. Part a·Yi-Jie PengShih-Jung Liu
Feb 28, 2016·American Journal of Ophthalmology·Ella H LeungLaura C Huang
Nov 15, 2017·Expert Opinion on Drug Metabolism & Toxicology·Magdalena EdingtonNgaihang Victor Chong
Sep 23, 2018·Journal of Cataract and Refractive Surgery·Kamal KishoreWilliam I Bond
Mar 20, 2020·Pharmaceutics·Rubén Varela-FernándezFrancisco J Otero-Espinar

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