Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.

Antimicrobial Agents and Chemotherapy
Baudouin BylJean-Pierre Thys

Abstract

Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).

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