PMID: 8477127Apr 1, 1993Paper

Vancomycin pharmacokinetics in neonates and infants: a retrospective evaluation

The Annals of Pharmacotherapy
W H AsburyC C Capers

Abstract

To evaluate the frequency with which current loading and maintenance vancomycin dosages achieve target serum concentrations based on pharmacokinetic parameters obtained after the initial dose. Also, to identify the daily vancomycin dosage necessary to achieve target serum concentrations at steady-state and to determine if any relationships exist between vancomycin pharmacokinetic parameters and various patient characteristics. Neonatal intensive care unit (NICU) at Georgia Baptist Medical Center. Twenty-three infants with suspected or documented gram-positive infection who received intravenous vancomycin between July 1990 and November 1991 were included in this retrospective analysis. Gestational age range from 23 to 41 weeks and postconceptional age (PCA) at the time of the study ranged from 26 to 46 weeks. Vancomycin therapy was initiated with a loading dose of 15 mg/kg, followed by a maintenance dosage of 20-30 mg/kg/d, which was usually given as 10 mg/kg q8-12h. All vancomycin doses were administered using a syringe pump. Peak and trough serum concentrations were obtained following the first dose. Vancomycin pharmacokinetic parameters were determined using a one-compartment model. Infants receiving indomethacin within two w...Continue Reading

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Citations

Jan 7, 1999·The Journal of Pharmacy and Pharmacology·R SilvaA C Falcão
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alan D TiceUNKNOWN IDSA
Dec 16, 1998·Therapeutic Drug Monitoring·M YasuharaR Hori
Jun 1, 1997·Therapeutic Drug Monitoring·M V MilesP McGinnis
May 14, 2004·Clinical Pharmacokinetics·Matthijs de HoogJohn N van den Anker
Mar 30, 2004·Antimicrobial Agents and Chemotherapy·Toshimi KimuraKazuo Yago
Nov 3, 2010·British Journal of Clinical Pharmacology·María-Remedios Marqués-MiñanaJosé-Esteban Peris
Dec 14, 2011·Clinical Pharmacokinetics·Amélie MarsotNicolas Simon
Aug 4, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuru IrikuraTetsumi Irie
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·Julianne KimAndrew Simor
Nov 28, 2012·Clinical Pharmacokinetics·Amélie MarsotNicolas Simon
Sep 12, 2002·Clinical Pharmacokinetics·Jane Alcorn, Patrick J McNamara
Oct 18, 2000·Therapeutic Drug Monitoring·R E WrishkoD Hamilton
Jul 11, 1998·Pediatric Hematology and Oncology·N KrivoyM W Ben Arush
Feb 6, 2017·Journal of Clinical Pharmacology·Gilbert KochMarc Pfister
Apr 26, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Brady S MoffettPaul A Checchia
Oct 31, 2002·Clinical Pharmacokinetics·Jane Alcorn, Patrick J McNamara
Jan 15, 2014·Neonatal Network : NN·Robin B Knobel, Jennifer Marie Smith
Aug 21, 2015·Expert Review of Clinical Pharmacology·Evelyne Jacqz-AigrainMike Sharland
Sep 2, 1998·British Journal of Clinical Pharmacology·F PawlotskyJ C Roze

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