PMID: 8591068Oct 1, 1995Paper

Vancomycin pharmacokinetics in spinal cord injured patients: a comparison with age-matched, able-bodied controls

The Journal of Spinal Cord Medicine
L A Lavezo, R L Davis

Abstract

To compare the pharmacokinetics of vancomycin in chronic spinal cord injured patients and hospitalized, age-matched, able-bodied controls, we evaluated 14 spinal cord injured patients and 14 controls. Pharmacokinetic parameters of total body clearance (CL), distribution volume (V), elimination rate constant (k) and elimination half-life (t1/2) were calculated from two steady-state vancomycin serum concentrations by the method of Sawchuk and Zaske. Demographic data such as age, ideal body weight (IBW), total body weight (TBW) and serum creatinine at start of therapy (SCr), pharmacokinetic parameters and predicted dosages to achieve specific peak (30 mcg/ml) and through concentrations (5-10 mcg/ml) were calculated for both groups. Statistical comparisons were made using a two sample, Student's t-test. Demographic data between groups differed only in mean serum creatinine (p = 0.04). There were no statistically significant differences in mean pharmacokinetic parameters of CL and V or mean predicted dosages. Mean elimination rate constant was significantly smaller and mean elimination half-life was significantly longer in spinal cord injured patients (p = 0.02 and p = 0.04, respectively). The longer dosing interval predicted in spi...Continue Reading

References

Jan 1, 1988·Pharmacotherapy·J L SegalI M Eltorai

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Citations

Dec 21, 2006·Spinal Cord·P García-LópezG Castañeda-Hernández
Sep 19, 2012·Journal of Neurosurgery. Spine·Diana S L ChowRobert G Grossman

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