Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis

Critical Care Medicine
Megan K LutherKerry L LaPlante

Abstract

The objective of this systematic review and meta-analysis was to assess acute kidney injury with combination therapy of vancomycin plus piperacillin-tazobactam, in general, adult patients and in critically ill adults. Rates of acute kidney injury, time to acute kidney injury, and odds of acute kidney injury were compared with vancomycin monotherapy, vancomycin plus cefepime or carbapenem, or piperacillin-tazobactam monotherapy. Studies were identified by searching Pubmed, Embase, Web of Science, and Cochrane from inception to April 2017. Abstracts from selected conference proceedings were manually searched. Articles not in English, pediatric studies, and case reports were excluded. Two authors independently extracted data on study methods, rates of acute kidney injury, and time to acute kidney injury. Effect estimates and 95% CIs were calculated using the random effects model in RevMan 5.3. Literature search identified 15 published studies and 17 conference abstracts with at least 24,799 patients. The overall occurrence rate of acute kidney injury was 16.7%, with 22.2% for vancomycin plus piperacillin-tazobactam and 12.9% for comparators. This yielded an overall number needed to harm of 11. Time to acute kidney injury was faste...Continue Reading

References

Dec 5, 1968·The New England Journal of Medicine·D S BaldwinG R Gallo
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·B F Farber, R C Moellering
Nov 24, 1998·The Annals of Pharmacotherapy·A O WaiF Marra
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
May 16, 2006·Critical Care : the Official Journal of the Critical Care Forum·Eric A J HosteJohn A Kellum
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Dec 25, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael RybakDonald P Levine
Jun 24, 2009·Intensive Care Medicine·Michael JoannidisPhilipp G H Metnitz
Jul 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas P LodiseGeorge L Drusano
Dec 24, 2010·Critical Care Medicine·Terry L Shirey
Mar 14, 2012·European Journal of Clinical Pharmacology·Sepideh ElyasiAmirhooshang Mohammadpour
Mar 14, 2012·BMJ Open·Jens-Ulrik Stæhr JensenUNKNOWN Procalcitonin And Survival Study (PASS) Group
Jun 5, 2013·The Journal of Surgical Research·Eric J LeyAli Salim
Jun 21, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Elizabeth LeungMarc H Scheetz
Sep 18, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Dorothy M SuppKathryn Glaser
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R P MoensterJ R McDonald
Apr 26, 2014·The American Journal of the Medical Sciences·Carlos A AlvarezRonald G Hall
Jun 17, 2014·Clinical Therapeutics·Sara E RostasMichael S Calderwood
Sep 18, 2014·Kidney International·Edward D Siew, Andrew Davenport
Nov 27, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Florentina E SileanuJohn A Kellum
Apr 18, 2015·BMC Nephrology·Kathy MacJeffrey Wong
Jul 1, 2015·Antimicrobial Agents and Chemotherapy·Jesse D SuttonJason M Pogue
Jul 2, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·L Nelson Sanchez-PintoRobinder G Khemani
Jul 15, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mo-Han DongAi-Dong Wen
Jul 15, 2015·Intensive Care Medicine·Eric A J HosteJohn A Kellum
Sep 26, 2015·Hospital Pharmacy·Jennifer WadeRobert Ragan
Oct 21, 2015·Surgical Infections·Stephen W DaviesRobert G Sawyer
Dec 23, 2015·Journal of Medical Microbiology·Michael A LorenzTravis W Linneman
Feb 3, 2016·Clinical Therapeutics·Kristen E FoderoKari A Mergenhagen
Feb 5, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·J Nicholas O'DonnellMarc H Scheetz
Jun 14, 2016·Therapeutic Advances in Endocrinology and Metabolism·Oluwatoyin Bamgbola
Jul 9, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shu-Ling FanDaniel G Remick
Jul 9, 2016·Critical Care : the Official Journal of the Critical Care Forum·John A Kellum, Raghavan Murugan

❮ Previous
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Citations

Jun 21, 2018·The Annals of Pharmacotherapy·Erin F BarretoJames M Steckelberg
Oct 4, 2018·PloS One·Brady S MoffettAyse Akcan-Arikan
Feb 9, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·T SchmochM A Weigand
Apr 7, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Mark A Perazella
Aug 31, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Diana J SchreierErin F Barreto
Apr 27, 2019·The European Respiratory Journal·Brandon J WebbNathan C Dean
Jun 4, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Keith A Rodvold
Aug 8, 2018·Der Anaesthesist·C J ReußT Brenner
Apr 9, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yoav Golan
Jan 7, 2020·The Journal of Antimicrobial Chemotherapy·Frederico Carlos de Sousa Arnaud, Alexandre Braga Libório
Nov 7, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Taylor M PatekChristopher R Frei
Feb 12, 2020·JAMA : the Journal of the American Medical Association·Steven Y C TongUNKNOWN Australasian Society for Infectious Diseases Clinical Research Network
May 8, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshiro SakaiHiroshi Watanabe
Oct 16, 2019·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Shunsuke InageShiro Katayama
Apr 22, 2020·Antimicrobial Agents and Chemotherapy·Kyle C MolinaDouglas N Fish
Dec 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sean N AvedissianMarc H Scheetz
Aug 19, 2020·Journal of Clinical Pharmacy and Therapeutics·Kelly L CovertPaul Lewis
Sep 25, 2019·Annals of Intensive Care·Stephan EhrmannUNKNOWN Clinical research in intensive care and sepsis-Trial group for global evaluation and research in sepsis (CRICS-TRIGGERSEP ne
Jun 5, 2019·Journal of Clinical Medicine·Ashley R Selby, Ronald G Hall
Sep 11, 2019·Journal of the American Society of Nephrology : JASN·Emily L JoyceJohn A Kellum
Dec 1, 2018·Journal of Veterinary Internal Medicine·Ian M DeStefanoJonathan M Babyak
Aug 30, 2019·Surgical Infections·M Paul NguyenEd Dominguez
Sep 19, 2020·The Journal of Antimicrobial Chemotherapy·J D WorkumR J Brüggemann
Jul 1, 2020·Expert Review of Anti-infective Therapy·Sofie DhaeseJan De Waele
Aug 8, 2018·JAMA Internal Medicine·Peter E Wu, Derek Leong
Oct 11, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Alice Jenh Hsu, Pranita D Tamma
Aug 14, 2020·Surgical Infections·Matthew S SussmanKenneth G Proctor

❮ Previous
Next ❯

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