Vancomycin population pharmacokinetics in neonates

Clinical Pharmacology and Therapeutics
M de HoogJ N van den Anker

Abstract

Recently the value of vancomycin therapeutic drug monitoring, as well as the required therapeutic range, has been subject of debate, resulting in new recommendations. This study was performed to incorporate these new insights in an up-to-date dosing scheme for neonates of various gestational ages. In this retrospective study with prospective validation, 108 newborns with suspected central line-related septicemia during the first month of life received 30 mg/kg/day vancomycin divided into two doses regardless of gestational or postconceptional age. Trough and peak vancomycin serum concentrations were determined before and after the third dose. Vancomycin data were analyzed according to a one-compartment open model with use of NONMEM population pharmacokinetic software. Model parameters were evaluated and then used to simulate vancomycin dosing for different dose and dose interval combinations. Targets were a trough concentration between 5 and 15 mg/L and a peak below 40 mg/L. In the prospective study, the optimal scheme was tested in 22 patients. Of the 108 patients, 34.3% of measured trough concentrations and 17.6% of peak concentrations were outside the desired therapeutic range. The model that best fitted the data included cl...Continue Reading

Citations

Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Dolores Santos BuelgaMaría José García
Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Gudrun WürthweinThomas J Walsh
Nov 26, 2010·BMC Pediatrics·N Margreth van der LugtFrans J Walther
Aug 21, 2015·Expert Review of Clinical Pharmacology·Evelyne Jacqz-AigrainMike Sharland
Aug 27, 2005·British Journal of Clinical Pharmacology·Hussain Mulla, Suneel Pooboni
Dec 4, 2003·Journal of Clinical Pharmacy and Therapeutics·E S El DesokyA Y Al Hammadi
Sep 29, 2015·Journal of Clinical Pharmacology·Jiraganya Jj BhongsatiernCatherine M T Sherwin
Apr 1, 2014·American Journal of Obstetrics and Gynecology·Cheryl N OnwuchurubaMarjorie S Brown
Jun 18, 2009·Journal of Clinical Pharmacology·Stephanie LäerBernd Meibohm
Sep 18, 2002·The Journal of Perinatal & Neonatal Nursing·Patricia Marie Dawson
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·Julianne KimAndrew Simor
Jan 21, 2016·Antimicrobial Agents and Chemotherapy·Stéphanie LerouxWei Zhao
Dec 9, 2015·Antimicrobial Agents and Chemotherapy·Esther J H JanssenCatherijne A J Knibbe
Sep 25, 2018·Journal of Clinical Pharmacology·Stephen J Balevic, Michael Cohen-Wolkowiez
Jan 14, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Trey CrumbyAjay J Talati
Nov 3, 2010·British Journal of Clinical Pharmacology·María-Remedios Marqués-MiñanaJosé-Esteban Peris
May 14, 2004·Clinical Pharmacokinetics·Matthijs de HoogJohn N van den Anker
Aug 4, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuru IrikuraTetsumi Irie
Oct 8, 2011·Expert Review of Clinical Pharmacology·Matthew M LaughonMichael Cohen-Wolkowiez
Dec 14, 2011·Clinical Pharmacokinetics·Amélie MarsotNicolas Simon
Nov 28, 2012·Clinical Pharmacokinetics·Amélie MarsotNicolas Simon
Nov 13, 2013·Paediatric Drugs·Chris StockmannCatherine M T Sherwin
Feb 20, 2016·Current Opinion in Infectious Diseases·Jodi M LestnerMike Sharland
Jan 30, 2015·The Pediatric Infectious Disease Journal·Theresa RingenbergMarc Sturgill
Aug 10, 2013·Archives of Disease in Childhood·Samira Samiee-Zafarghandy, John N van den Anker
Apr 26, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Brady S MoffettPaul A Checchia
Jun 9, 2020·Paediatric Drugs·Robert B Flint, Karel Allegaert
Oct 22, 2014·Paediatrics & Child Health·Deonne Dersch-MillsKamran Yusuf
Mar 19, 2021·Scientific Reports·Soon Min LeeMin Jung Chang
Apr 4, 2021·Antibiotics·Marta Mejías-TruebaMaria Victoria Gil-Navarro
May 19, 2021·Clinical Pharmacokinetics·Erin ChungWinnie Seto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.