Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Nadezda PetejovaIvana Kacirova

Abstract

To determine the extent of vancomycin removal and vancomycin pharmacokinetics in septic patients with AKI using daily hemodialysis with polysulphone high-flux and low-flux membrane. Five patients received 6 h daily dialysis with low-flux polysulphone membrane, four patients with high-flux polysulphone membrane. Vancomycin was administered over the last hour of dialysis. The maintenance dose was adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Median percentage of vancomycin removal by low-flux membrane dialysis was 17% (8-38%) and by high-flux membrane dialysis was 31% (13-43%). Vancomycin clearance was only moderately higher in high-flux membrane dialysis (median 3.01 L/h, range 2.34-3.5 L/h) compared to low-flux dialysis (median 2.48 L/h, range 0.53-5.68 L/h) in the first day of the study. About two-fold higher vancomycin clearance in high-flux dialysis (median 3.62 L/h, range 1.37-5.07 L/h) was observed on the second day of the study than low-flux dialysis (median 1.74 L/h, range 0.75-30.94 L/h). Both high-flux and low-flux membrane dialysis remove considerable amounts of vancomycin in critically ill septic patients with AKI. Application of vancomycin after each dialysis was re...Continue Reading

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Citations

Feb 24, 2015·Diagnostic Microbiology and Infectious Disease·Janattul-Ain JamalJason A Roberts
Nov 8, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Nadezda PetejovaIvana Kacirova
Jan 31, 2018·Hemodialysis International·Heather A NymanAlfred K Cheung
Jan 10, 2019·Clinical and Experimental Pharmacology & Physiology·Welder ZamonerDaniela Ponce
Feb 15, 2014·Current Opinion in Infectious Diseases·Deirdre J O'Brien, Ian M Gould
Jan 18, 2017·Pharmacology Research & Perspectives·Welder ZamonerDaniela Ponce
Oct 27, 2015·International Journal of Clinical Pharmacy·Jian P MeiBruce A Mueller
Sep 24, 2020·International Journal of Environmental Research and Public Health·Fernanda Moreira de FreitasDaniela Ponce
Sep 18, 2020·International Journal of Antimicrobial Agents·Suzanne L ParkerJason A Roberts

Related Concepts

Antibiotics
Hemodialysis
AB-Vancomycin
Pyemia
Dialysis Procedure
Kidney Failure, Acute
Drug Kinetics
Vancomycin
Polysulfone
Membrane

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