PMID: 8946660Dec 1, 1996Paper

Vancomycin serum concentrations in patients with renal dysfunction: a comparison of fluorescence polarization immunoassay and the enzyme-multiplied immunoassay technique

Therapeutic Drug Monitoring
H J PeckmanR E Cross

Abstract

A study was conducted to determine whether assay-specific quantitative differences exist in the determination of vancomycin serum concentrations obtained from patients with renal dysfunction. Vancomycin serum concentrations were obtained during the first week of therapy for each of three time intervals: 48-96 h, 96-144 h, and 144-192 h after administration of the first dose of vancomycin. Vancomycin serum concentrations were measured using the enzyme-multiplied immunoassay technique (EMIT) and fluorescence polarization immunoassay (FPIA). Twenty patients with an estimated creatinine clearance < 40 ml/min who were receiving intravenous vancomycin were evaluated. Hemodialysis was required in 16 of 20 patients. Fifty samples were included in the data analysis. The mean (+/-SD) serum concentrations obtained with EMIT and FPIA were 10.9 mg/L (+/-5.3) and 12.6 mg/L (+/-5.7), respectively (p = 0.13), and were not statistically different. A linear relationship was observed between EMIT and FPIA (EMIT = 0.89 x FPIA - 0.24; r2 = 0.93). No statistically significant differences were observed in the calculated pharmacokinetic parameters between methods. FPIA and EMIT are comparable methods in determining vancomycin serum concentrations with...Continue Reading

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Citations

Feb 7, 2008·Seminars in Dialysis·Katie E Pallotta, Harold J Manley
Feb 14, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yasuhiro SakamotoKoichi Saito
Jan 12, 2000·The Annals of Pharmacotherapy·P F Smith, G D Morse
Mar 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiajing WangGuorong Fan
Feb 1, 2006·Rapid Communications in Mass Spectrometry : RCM·J DianaE Adams

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