Vanilloid receptors mediate adrenergic nerve- and CGRP-containing nerve-dependent vasodilation induced by nicotine in rat mesenteric resistance arteries

British Journal of Pharmacology
Shinji EguchiHiromu Kawasaki

Abstract

Previous studies showed that nicotine induces adrenergic nerve-dependent vasodilation that is mediated by endogenous calcitonin gene-related peptide (CGRP) released from CGRP-containing (CGRPergic) nerves. The mechanisms underlying the nicotine-induced vasodilation were further studied. Rat mesenteric vascular beds without endothelium were contracted by perfusion with Krebs solution containing methoxamine, and the perfusion pressure was measured with a pressure transducer. Perfusion of nicotine (1-100 microm) for 1 min caused concentration-dependent vasodilation. Capsazepine (vanilloid receptor-1 antagonist; 1-10 microm) and ruthenium red (inhibitor of vanilloid response; 1-30 microm) concentration-dependently inhibited the nicotine-induced vasodilation without affecting the vasodilator response to exogenous CGRP. Nicotine-induced vasodilation was not inhibited by treatment with 3,4-dihydroxyphenylalanine (DOPA) receptor antagonist (l-DOPA cyclohexyl ester; 0.001-10 microm), dopamine D1 receptor-selective antagonist (SCH23390; 1-10 microm), dopamine D2 receptor antagonist (haloperidol; 0.1-0.5 microm), ATP P2x receptor-desensitizing agonist (alpha,beta-methylene ATP; 1-10 microm), adenosine A2 receptor antagonist (8(p-sulfophen...Continue Reading

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Citations

Jul 1, 2007·Neuromodulation : Journal of the International Neuromodulation Society·Mingyuan WuRobert D Foreman
Oct 5, 2010·Acta Physiologica·H KawasakiY Kitamura
Dec 18, 2007·Autonomic Neuroscience : Basic & Clinical·Mingyuan WuRobert D Foreman
Jan 8, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Erika B Westcott, Steven S Segal
Aug 15, 2014·British Journal of Pharmacology·Shingo TakatoriHiromu Kawasaki
Dec 13, 2005·European Journal of Pharmacology·Honghua JinHiromu Kawasaki
Oct 22, 2019·Journal of Cardiovascular Pharmacology·Hsi-Hsien ChangShang-Jen Chang
Mar 12, 2015·The Clinical Journal of Pain·Thomas M KinfeHartmut Vatter
Oct 12, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Panot TangsucharitHiromu Kawasaki
Apr 9, 2020·Journal of Cardiovascular Pharmacology·Kuo-Feng HuangShang-Jen Chang
Jun 21, 2013·Journal of Pharmacological Sciences·Carolina Rocha-PereiraCarmen Diniz
Dec 4, 2020·Physiological Reviews·Christian AalkjærJo G R De Mey

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