Vanishing lung syndrome and HIV infection: an uncommon yet potentially fatal sequela of cigarette smoking

Journal of the International Association of Physicians in AIDS Care : JIAPAC
Deepthi ManiDavid M Aboulafia

Abstract

Persons with HIV infection have a higher risk of infectious pulmonary complications, chronic obstructive pulmonary disease, lung cancer, pulmonary hypertension, and pulmonary fibrosis than individuals not infected with HIV. Herein, we describe the clinical course of a patient with longstanding and well-controlled HIV infection and multiple previous pneumothoraces who presented to medical attention with insidious onset of shortness of breath and was diagnosed with vanishing lung syndrome (VLS). The VLS or giant bullous emphysema is a distinct clinical syndrome characterized by large bullae, predominantly in the upper lobes, occupying at least one third of the hemithorax and compressing surrounding normal lung parenchyma. It is a progressive disorder that typically occurs in young men, the majority of whom are smokers. As people with HIV/AIDS are now surviving well into middle age and beyond, clinicians are more likely to encounter VLS and severe obstructive lung disease, which are potentially fatal but preventable conditions.

References

Mar 15, 1991·Annals of Internal Medicine·K A SepkowitzD Armstrong
Feb 1, 1994·AJR. American Journal of Roentgenology·E J SternN L Müller
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·J M WallaceP C Hopewell
Feb 26, 2000·Annals of Internal Medicine·P T DiazT L Clanton
Jan 28, 2003·Cleveland Clinic Journal of Medicine·Pyng LeeJames K Stoller
Jul 11, 2003·Lancet·A MocroftUNKNOWN EuroSIDA study group
Feb 17, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Martha M YearsleyGerard J Nuovo
Jun 8, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rakhi KohliUNKNOWN HER Study Group
Nov 14, 2006·Chest·Kristina CrothersUNKNOWN Veterans Aging Cohort 5 Project Team
May 16, 2007·Journal of General Internal Medicine·Kristina CrothersAmy C Justice
Aug 28, 2007·Clinics in Chest Medicine·Kristina Crothers
Nov 8, 2007·Medicine and Science in Sports and Exercise·Andrew Mark LuksErik R Swenson
Jun 21, 2008·European Journal of Radiology·Antonio RiveroUNKNOWN Andalusian Group for the Study of Infectious Diseases (GAEI)
Jul 12, 2008·American Journal of Respiratory and Critical Care Medicine·Fred M GordinLeonard N Slater
Aug 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A BertaniB Gridelli
Mar 11, 2010·AIDS Patient Care and STDs·Linda DrachLaura Chisholm Saddler
Aug 21, 2010·American Journal of Public Health·Alan R LifsonUNKNOWN INSIGHT SMART Study Group
Sep 21, 2010·American Journal of Respiratory and Critical Care Medicine·Kristina CrothersAmy C Justice
Jun 15, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Damon J VidrineEllen R Gritz
Aug 2, 2011·Clinical Lung Cancer·Deepthi ManiDavid M Aboulafia
Aug 4, 2011·Expert Review of Anti-infective Therapy·Kristina Crothers, Hilary A Tindle

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.