Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports

International Journal of Impotence Research
S MarkouG Barbalias

Abstract

Trials of the efficacy and safety of vardenafil in the treatment of male erectile dysfunction (ED) were meta-analysed. All available databases were searched (January 1, 2001-November 30, 2003). Trials were eligible if they included men with ED, compared vardenafil with placebo, were randomized, were at least of 12 weeks duration, and assessed clinically relevant outcomes. Two reviewers independently evaluated study quality and extracted data in a standardized fashion. Nine trials (6809 men) met the inclusion criteria. In results pooled from seven fixed-dose trials, vardenafil increases the Erectile Function domain of the International Index of Erectile Function questionnaire by 6.18 units (weighted mean difference (WMD)). Vardenafil also increases the percentage of erections firm enough to allow vaginal penetration (WMD: 26) and the percentage of sexual attempts that were successful per participant (WMD: 29.8). The percentage of men agreeing with the statement that 'the treatment they have been taking over the past 4 weeks improved their erections', is also in favour of vardenafil (relative risk (RR): 3). These efficacy variables appeared greater at higher doses, although there are no significant differences between 10 and 20 m...Continue Reading

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Citations

May 26, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Mariacristina VecchioGiovanni F M Strippoli
Feb 24, 2006·Asian Journal of Andrology·P PerimenisA Athanasopoulos
Jun 7, 2005·Expert Opinion on Drug Safety·Thorsten Reffelmann, Robert A Kloner
Apr 14, 2009·Social Science & Medicine·Emily Wentzell, Jorge Salmerón
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Sep 18, 2013·The World Journal of Men's Health·Ji Kan RyuSoo Woong Kim
Feb 16, 2005·Expert Opinion on Pharmacotherapy·Françoise Meunier

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