Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice.

Neurobiology of Learning and Memory
Danielle Gulick, Thomas J Gould

Abstract

Ethanol is a frequently abused drug that impairs cognitive processes such as learning. Varenicline, an alpha4beta2 nicotinic receptor partial agonist and alpha7 nicotinic receptor full agonist prescribed for smoking cessation, has been shown to decrease ethanol consumption. The current study investigated whether varenicline could ameliorate ethanol-induced deficits in learning and whether varenicline alters blood alcohol concentration in C57BL/6 mice. Conditioning consisted of two auditory conditioned stimulus (CS; 30s, 85dB white noise)-foot shock unconditioned stimulus (US; 2s, 0.57mA) pairings. For all studies, saline or ethanol (1.0, 1.5, 2.0g/kg i.p.) was administered 15min before training, and saline or varenicline (0.05, 0.1, 0.2mg/kg i.p.) was administered 60min before either training or testing. For blood alcohol analysis, saline or varenicline (0.1mg/kg) was administered 60min before collection, and saline or ethanol (1.0, 1.5, 2.0g/kg) was administered 15min before collection. Varenicline dose-dependently ameliorated ethanol-induced conditioning deficits for all three doses of ethanol when administered before training but not when administered 24h later, before testing. In addition, varenicline did not alter blood al...Continue Reading

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Citations

Jun 10, 2015·Neuroscience and Biobehavioral Reviews·F Scott HallJared W Young
Feb 7, 2012·Annals of the New York Academy of Sciences·F Scott HallGeorge R Uhl
Mar 19, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tugba GoktalayGokhan Goktalay
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Jul 26, 2012·Alcoholism, Clinical and Experimental Research·Leandro SandayRoberto Frussa-Filho

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