PMID: 2503586Jan 1, 1989Paper

Variability among brain regions in the specificity of 6-hydroxydopamine (6-OHDA)-induced lesions

Journal of Neural Transmission
D L ComminsL S Seiden

Abstract

6-Hydroxydopamine (6-OHDA; 200 micrograms, 150 micrograms or 110 micrograms) or vehicle was infused stereotaxically into the lateral ventricles of rats, usually following pretreatment with desmethylimipramine (DMI). Various brain regions were then assayed for dopamine (DA), serotonin (5-HT) and norepinephrine (NE). As expected, 6-OHDA depleted DA in all brain regions examined. Unexpectedly, however, the two highest doses of 6-OHDA significantly decreased 5-HT levels in the hippocampus and increased 5-HT levels in the striatum. In addition, despite pretreatment with doses of DMI commonly considered adequate to block 6-OHDA-induced depletion of NE, all doses of 6-OHDA tested significantly reduced NE levels in the hippocampus, hypothalamus and septum. We interpret our data as suggesting that some brain regions are susceptible to nonspecific toxic effects of 6-OHDA at doses commonly employed. Furthermore, these nonspecific effects may or may not occur, depending on seemingly minor variations in experimental technique.

References

Oct 5, 1979·Brain Research·O S GershanikR C Duvoisin
May 1, 1972·European Journal of Pharmacology·B R JacksJ P Cordeau
Feb 1, 1970·Journal of Neurochemistry·N J Uretsky, L L Iversen
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Jan 1, 1980·Annual Review of Neuroscience·G Jonsson
Jan 1, 1984·Journal of Neural Transmission·T A Reader, P Gauthier
Apr 9, 1981·European Journal of Pharmacology·R Ings, B Pappas
Jan 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Mason, C Weinkove
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·T G HeffnerL S Seiden

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Citations

Sep 1, 2011·Progress in Neurobiology·Philippe HuotJonathan M Brotchie
Apr 30, 2010·The International Journal of Neuropsychopharmacology·Cristina MiguelezLuisa Ugedo

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