Variability and habituation of nystagmic responses to hot caloric stimulation of normal subjects. Evidence that this test may be inapplicable to monitoring drug-induced vestibular toxicity

The Journal of Laryngology and Otology
P G DaveyP M Shenoi

Abstract

Experiments were performed on 25 otoneurologically "normal' subjects to evaluate the hot caloric test as a screening test for aminoglycoside vestibular toxicity. Using portable equipment under non-ideal conditions, it was found that there was a large inter-subject variability in nystagmic response and that, instead of a random test-retest variability, a systematic variation in response occurred on repeated caloric stimulation with water at 44 degrees C. A response decline (habituation) evident in both the maximum slow phase velocity and the maximum frequency occurred at second test, although the inter-test interval ranged from 24 to 72 hours. After a 3-month interval with no intervening tests, the mean value of the maximum frequency reverted back to the original level. However, there was still a significant reduction in maximum slow phase velocity at this time. Some individuals had a sustained reduction in both parameters. Hence it is concluded that the hot caloric test, used under the conditions described in this study, is not a suitable serial screening method for aminoglycoside vestibular toxicity. The reproducibility of this test under other conditions, or any other caloric test, should be established in normal subjects bef...Continue Reading

References

Sep 1, 1978·Acta Oto-laryngologica·O WinkelK Rozarth
Sep 1, 1977·The Annals of Otology, Rhinology & Laryngology. Supplement·R W BalohV Honrubia
Sep 1, 1977·The Annals of Otology, Rhinology & Laryngology. Supplement·R W BalohV Honrubia
Sep 1, 1977·The Annals of Otology, Rhinology & Laryngology. Supplement·A W SillsV Honrubia
May 1, 1978·The Journal of Antimicrobial Chemotherapy·W E FeeG R Lathrop
Sep 1, 1973·The Laryngoscope·V S DayalB Kuzin
Oct 1, 1971·Archives of Otolaryngology·H O BarberF Demanuele
Dec 1, 1965·The Annals of Otology, Rhinology, and Laryngology·W E Collins
Jun 1, 1969·The Annals of Otology, Rhinology, and Laryngology·N Torok
Feb 1, 1967·The Journal of Laryngology and Otology·R Hinchcliffe
Jan 1, 1967·Acta Oto-laryngologica·R Hinchcliffe
Feb 1, 1962·Journal of Experimental Psychology·W E COLLINS
Jul 1, 1962·Acta Oto-laryngologica·E FLUUR, L MENDEL
Feb 1, 1965·The Laryngoscope·C W HART
Apr 1, 1965·Archives of Otolaryngology·L BERNSTEIN

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Citations

Dec 1, 1984·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·N S Longridge, A I Mallinson
Feb 1, 2018·American Journal of Audiology·Elizabeth BurnetteDennis Frank-Ito
Jan 1, 1993·Acta Oto-laryngologica. Supplementum·H ShojakuC Sekiguchi

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