Variability and reliability of effective connectivity within the core default mode network: A multi-site longitudinal spectral DCM study

NeuroImage
Hannes AlmgrenDaniele Marinazzo

Abstract

Dynamic causal modelling (DCM) for resting state fMRI - namely spectral DCM - is a recently developed and widely adopted method for inferring effective connectivity in intrinsic brain networks. Most applications of spectral DCM have focused on group-averaged connectivity within large-scale intrinsic brain networks; however, the consistency of subject- and session-specific estimates of effective connectivity has not been evaluated. Establishing reliability (within subjects) is crucial for its clinical use; e.g., as a neurophysiological phenotype of disease progression. Effective connectivity during rest is likely to vary due to changes in cognitive, and physiological states. Quantifying these variations may help understand functional brain architectures - and inform clinical applications. In the present study, we investigated the consistency of effective connectivity within and between subjects, as well as potential sources of variability (e.g., hemispheric asymmetry). We also addressed the effects on consistency of standard data processing procedures. DCM analyses were applied to four longitudinal resting state fMRI datasets. Our sample comprised 17 subjects with 589 resting state fMRI sessions in total. These data allowed us t...Continue Reading

Citations

Jan 16, 2020·Expert Review of Neurotherapeutics·Jan Kassubek, Hans-Peter Müller
May 1, 2020·Brain : a Journal of Neurology·Egill Axfjord FridgeirssonDamiaan Denys
Sep 21, 2019·Nature Communications·Caio SeguinAndrew Zalesky
Feb 28, 2020·Scientific Reports·Fabrizio Parente, Alfredo Colosimo
Jun 25, 2019·Frontiers in Behavioral Neuroscience·Fan Zhang, Sunao Iwaki
Dec 4, 2020·Psychological Medicine·Ashish K SahibKatherine L Narr
Feb 5, 2021·Human Brain Mapping·Stefan FrässleKlaas E Stephan
Nov 21, 2019·NeuroImage·Frederik Van de SteenDaniele Marinazzo
Jun 10, 2021·Journal of Central Nervous System Disease·Sahil BajajWilliam Ds Killgore
Aug 1, 2021·Scientific Reports·Fabrizio Parente, Alfredo Colosimo
Nov 30, 2021·The European Journal of Neuroscience·Kelly A VaughnLinda Ewing-Cobbs
Jan 5, 2022·Human Brain Mapping·Myrthe G RijpmaKatherine P Rankin

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Methods Mentioned

BETA
PCA

Software Mentioned

spm
dcm
MyConnectome
SPM12
peb

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