Variability in adherence to rhGH treatment: Socioeconomic causes and effect on children's growth

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Silvina De PedroJoan Bel

Abstract

In children with growth disorders, mean final height is associated to poor adherence to Growth Hormone therapy. The primary goal of this study is to identify patients who do not adhere to GH therapy and determine the influence of adherence in response to the treatment. The role of serum IGF-I and influence of socio-economic factors on the therapeutic adherence will also be evaluated. 158 children under treatment with rhGH were included in the study. Age, gender, etiology, Tanner stage, duration of treatment, growth rate, IGF-I serum values, daily dose, and annual rhGH dose data were collected. Adherence to therapy was defined as moderate-to-poor when the patient had taken less than 92% of the prescribed medication. A subgroup of 106 patients completed a questionnaire to assess social and environmental effects. Moderate-to-poor adherence to rhGH treatment was determined in 33.5% of study patients. A decrease in adherence was associated to treatment duration (p=0.001). A significant correlation was determined between adherence and height velocity (p=0.002) and IGF-I (p<0.0001) levels. Adherence rates were associated to the mother's educational level (p=0.007). Poor adherence to GH therapy was observed in one-third of study patien...Continue Reading

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Citations

Nov 5, 2016·Expert Opinion on Drug Delivery·Tilman R RohrerAnne-Marie Kappelgaard
Jun 15, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Francesca BagnascoUNKNOWN Adherence Investigators Group *
Dec 8, 2020·Endocrine·Antonio de Arriba MuñozJosé Ignacio Labarta Aizpún
Feb 11, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Selina GrahamJohn Weinman
May 18, 2021·BioMed Research International·Qianqian ZhaoBo Ban
Jul 3, 2021·Journal of Clinical Medicine·Anna Sjöström, Charlotte Höybye
May 1, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Toshiaki TanakaAdeeb Tawseef

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