Variability in integration of mechanisms associated with high tolerance to progressive reductions in central blood volume: the compensatory reserve

Physiological Reports
Robert CarterVictor A Convertino

Abstract

High tolerance to progressive reductions in central blood volume has been associated with higher heart rate (HR), peripheral vascular resistance (PVR), sympathetic nerve activity (SNA), and vagally mediated cardiac baroreflex sensitivity (BRS). Using a database of 116 subjects classified as high tolerance to presyncopal-limited lower body negative pressure (LBNP), we tested the hypothesis that subjects with greater cardiac baroreflex withdrawal (i.e., BRS > 1.0) would demonstrate greater LBNP tolerance associated with higher HR, PVR, and SNA. Subjects underwent LBNP to presyncope. Mean and diastolic arterial pressure (MAP; DAP) was measured by finger photoplethysmography and BRS (down sequence) was autocalculated (WinCPRS) as ∆R-R Interval/∆DAP. DownBRS : ms/mmHg) was used to dichotomize subjects into two groups (Group 1 = DownBRS > 1.0, N = 49, and Group 2 = DownBRS < 1.0, N = 67) at the time of presyncope. Muscle SNA was measured directly from the peroneal nerve via microneurography (N = 19) in subjects from Groups 1 (n = 9) and 2 (n = 10). Group 1 (DownBRS > 1.0) had lower HR (107 ± 19 vs. 131 ± 20 bpm), higher stroke volume (45 ± 15 vs. 36 ± 15 mL), less SNA (45 ± 13 vs. 53 ± 7 bursts/min), and less increase in PVR (4.1 ± 1...Continue Reading

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Citations

Jul 6, 2016·Frontiers in Physiology·Anne-Sophie G T BronzwaerJohannes J van Lieshout
May 4, 2017·The Journal of Trauma and Acute Care Surgery·Steven L MoultonDavid MacLeod
Dec 19, 2017·The Journal of Trauma and Acute Care Surgery·Nicholas CaputoJason West
Dec 13, 2018·Physiological Reviews·Nandu GoswamiVictor A Convertino
Sep 27, 2018·International Journal of Veterinary Science and Medicine·O E Ola-DaviesM O Abatan
Aug 3, 2018·Journal of Intensive Care Medicine·Mithun R SureshVictor A Convertino
Feb 12, 2020·The Journal of Trauma and Acute Care Surgery·Taylor E SchlotmanVictor A Convertino
Apr 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carmen Hinojosa-LabordeVictor A Convertino
Sep 21, 2017·The Journal of Trauma and Acute Care Surgery·Michael Craig JohnsonBrian J Eastridge
Dec 29, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Taylor Elyse SchlotmanVictor A Convertino
Oct 10, 2020·The Journal of International Medical Research·Dan ChenJiujun Li
Nov 5, 2019·Journal of Pediatric Surgery·David K LeopoldSteven L Moulton

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Methods Mentioned

BETA
pregnancy test
feature extraction

Software Mentioned

WinDAQ
WinCPRS

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