Abstract
Genes involved in the metabolic activation or detoxification of environmental carcinogens may contribute to breast cancer susceptibility by influencing rates of somatic mutation. To examine this hypothesis, we studied the association between loss of constitutional heterozygosity (LOH) in ductal breast tumors and allelic variability in genes that regulate the metabolism of environmental carcinogens. LOH was measured by typing the tumor and normal tissue of 28 breast cancer cases at 33 chromosomal loci by using highly polymorphic tetranucleotide repeat markers. Genotypes in non-tumor tissue were also measured at the cytochrome P450 1A1 (CYP1A1), cytochrome P450 2D6 (CYP2D6), glutathione-s-transferase mu (GSTM), epoxide hydrolase (EH), and NAD(P)H:quinone oxidoreductase (NQO1) loci. The observed proportion of LOH was 11% overall and ranged from 0% to 37% across loci. LOH greater than 20% was observed on chromosomes 1p, 2p, 10q, 11q, 17p, and 18q. The observed proportion of LOH ranged from 0% to 67% among individuals. An elevated proportion of LOH was observed for genotypes at CYP2D6 (17% for the 1/1 and 1/2 genotypes vs 8% for the 2/ 2 genotype), NQO1 (13% for the 1/2 and 2/2 genotypes vs 8% for the 1/1 genotype), and GSTM (15% fo...Continue Reading
References
Apr 1, 1992·Journal of the National Cancer Institute·L C ChenH S Smith
Oct 1, 1991·Journal of Biochemistry·S HayashiK Kawajiri
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C S CroppR Callahan
Oct 1, 1990·British Journal of Cancer·A L BørresenJ M Nesland
Oct 25, 1990·Nature·A C GoughC R Wolf
Dec 10, 1990·Science·D MalkinM A Tainsky
Apr 1, 1991·Mutation Research·G S Omenn
Jan 1, 1990·Pharmacology & Therapeutics·P BoardG Webb
Jan 1, 1990·British Journal of Cancer·A M ThompsonH J Evans
Jun 25, 1990·Nucleic Acids Research·K E ComstockW D Henner
Dec 7, 1989·Nature·J M NigroP Devilee
Oct 1, 1989·Genomics·P DevileeC J Cornelisse
Dec 17, 1988·Lancet·J MackayH J Evans
Jan 1, 1987·Annual Review of Biochemistry·D W Nebert, F J Gonzalez
Aug 1, 1993·British Journal of Cancer·N A GruisC J Cornelisse
Jul 30, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·R CallahanD S Lisicia
Aug 1, 1995·Pharmacogenetics·E A RosvoldK H Buetow
Citations
Jan 14, 2000·Mutation Research·H Autrup
Feb 3, 2004·Environmental Health Perspectives·Jane A McElroyPatrick L Remington
Dec 20, 2003·Pharmacogenomics·Stella C LymberisSilvia C Formenti
Nov 24, 2004·Drug Metabolism Reviews·David Ross
Feb 24, 1999·Molecular Carcinogenesis·J D HaagM N Gould
Feb 19, 2011·Genetic Testing and Molecular Biomarkers·Virendra SinghMahendra Pratap Singh
Mar 3, 2011·Journal of Neurosurgery. Pediatrics·Pawel G OchalskiIan F Pollack
Aug 23, 2005·Carcinogenesis·Bin XiePeter G Shields