PMID: 6587716Jan 1, 1983Paper

Variability in Parkinson's disease; clinical aspects, causes and treatment

Acta Neurologica Scandinavica. Supplementum
J D Parkes

Abstract

As we have earlier shown, sudden extreme changes in disease severity are a characteristic feature of Parkinson's disease. These variations take two main forms, those natural to the disease and those occurring as a result of treatment. Treatment-related response variations can sometimes be attributed to the known pharmacokinetic properties of anti-parkinsonian drugs and, in particular, levodopa. These responses are time-dependent. In contrast, other types of response variation may be unpredictable in time, and are at present rarely amenable to treatment. Identification of the cause of variation is necessary for the management of parkinsonism, and particularly for the successful use of deprenyl.

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Citations

Aug 24, 1990·Pharmaceutisch Weekblad. Scientific Edition·A J Loonen, G J Zwanikken
Mar 23, 2004·Sleep Medicine·Stefania Brotini, Gian Luigi Gigli
Dec 20, 1996·Psychiatry Research·F BenedettiE Smeraldi
Jul 2, 2008·Parkinsonism & Related Disorders·P K PalJ A Fleming
Jan 1, 1983·Acta Neurologica Scandinavica. Supplementum·U K Rinne
Apr 3, 2012·The International Journal of Neuroscience·Anthony Barber, Khashayar Dashtipour
Mar 12, 2003·Sleep Medicine Reviews·Diego Garcia-BorregueroMauricio Bravo
Jul 1, 1987·Journal of Advanced Nursing·A NorbergB Winblad
Jul 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·M MerelloR Leiguarda
Feb 8, 1991·Death Studies·L E Lagrand
Nov 1, 1987·British Journal of Clinical Pharmacology·A L LeemanS M Dobbs

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