Variability in prescription opioid intake and reinforcement amongst 129 substrains

Genes, Brain, and Behavior
S M JimenezK K Szumlinski

Abstract

Opioid abuse in the United States has reached epidemic proportions, with treatment admissions and deaths associated with prescription opioid abuse quadrupling over the past 10 years. Although genetics are theorized to contribute substantially to inter-individual variability in the development, severity and treatment outcomes of opioid abuse/addiction, little direct preclinical study has focused on the behavioral genetics of prescription opioid reinforcement and drug-taking. Herein, we employed different 129 substrains of mice currently available from The Jackson Laboratory (129S1/SvlmJ, 129X1/SvJ, 129S4/SvJaeJ and 129P3/J) as a model system of genetic variation and assayed mice for oral opioid intake and reinforcement, as well as behavioral and somatic signs of dependence. All substrains exhibited a dose-dependent increase in oral oxycodone and heroin preference and intake under limited-access procedures and all, but 129S1/SvlmJ mice, exhibited oxycodone reinforcement. Relative to the other substrains, 129P3/J mice exhibited higher heroin and oxycodone intake. While 129X1/SvJ exhibited the highest anxiety-like behavior during natural opioid withdrawal, somatic and behavior signs of precipitated withdrawal were most robust in 12...Continue Reading

References

Jul 1, 1978·The American Journal of Psychiatry·B Stimmel, S D Glick
Apr 29, 1977·Psychopharmacology·G P HorowitzF K Stephan
Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·K A KhavariA S Wilson
Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·K Njung'e, S L Handley
Jan 1, 1991·Journal of Addictive Diseases·J M CarneyT W Seale
Apr 1, 1990·Alcoholism, Clinical and Experimental Research·J C CrabbeJ K Belknap
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·J K Belknap
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·J N Crawley
Jan 1, 1988·Psychopharmacology·M L ForgieB K Alexander
Mar 1, 1981·Behavior Genetics·J P Hegmann, B Possidente
Jan 1, 1993·Psychopharmacology·J K BelknapL A O'Toole
Sep 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D W Melton
Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D W ThreadgillT Magnuson
Aug 26, 1998·Drug and Alcohol Dependence·M J Kreek, G F Koob
May 26, 1999·Pharmacology, Biochemistry, and Behavior·G E HomanicsL L Firestone
Aug 3, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M F FestingL E Mobraaten
Nov 20, 2002·Chemical Senses·Michael G Tordoff, Alexander A Bachmanov
Feb 26, 2003·European Journal of Pharmacology·Michel Bourin, Martine Hascoët
Oct 28, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas N FerraroWade H Berrettini
Jan 12, 2005·Physiology & Behavior·Justin S RhodesJohn C Crabbe
Jan 12, 2005·Physiology & Behavior·Xiangdong Tang, Larry D Sanford
Mar 15, 2005·Psychopharmacology·Deborah A FinnJohn C Crabbe
Jul 5, 2005·Nature Reviews. Genetics·David GoldmanFrancesca Ducci
Jun 9, 2006·Addiction Biology·Carla Sanchis-Segura, Rainer Spanagel
Sep 12, 2006·Addiction Biology·Richard L BellWilliam J McBride
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Glenn A DoyleThomas N Ferraro
Sep 9, 2008·Drug and Alcohol Dependence·Pamela MettenJohn K Belknap
Sep 12, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yong ZhangMary Jeanne Kreek
Oct 29, 2010·Clinical Pharmacology and Therapeutics·M K HoR F Tyndale
Sep 17, 2011·Nature·Thomas M KeaneDavid J Adams
Apr 7, 2012·Journal of Opioid Management·Navid Khalili, Shahrokh Sardarpour Gudarzi
May 2, 2012·Human Genetics·Orna LevranMary Jeanne Kreek
May 30, 2012·The Psychiatric Clinics of North America·Francesca Ducci, David Goldman
May 16, 2013·Journal of Pain & Palliative Care Pharmacotherapy·Kenneth KirshJohn Coleman
Aug 24, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Debra K CozzoliKaren K Szumlinski
Nov 19, 2013·The International Journal on Drug Policy·Sarah G MarsDaniel Ciccarone

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Citations

Sep 9, 2018·Disease Models & Mechanisms·John P Sundberg, Paul N Schofield
Jan 29, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ashley N WatsonAndy Y Shih
Dec 13, 2019·Addiction Biology·Hannah D FulenwiderJesse R Schank
May 1, 2021·Journal of Personalized Medicine·Lynn M OswaldCarla L Storr

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