Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry

American Journal of Physiology. Lung Cellular and Molecular Physiology
J Jane PillowPeter D Sly

Abstract

Antenatal exposure to intra-amniotic (i.a.) endotoxin initiates a complex series of events, including an inflammatory cascade, increased surfactant production, and alterations to lung structure. Using the low frequency forced oscillation technique as a sensitive tool for measurement of respiratory impedance, we aimed to determine which factors contributed most to measured changes in lung mechanics. Respiratory impedance data obtained from sedated preterm lambs exposed to either i.a. injection with saline or 20 mg of endotoxin 1, 2, 4, and 15 days before delivery at 125 days gestation were studied, and association with indexes of standard lung morphometry, inflammatory response, and alveolar surfactant-saturated phosphatidylcholine (Sat PC) pool size was demonstrated. Reduction in tissue impedance with increasing interval between exposure and delivery was evident as early as 4 days after i.a. endotoxin injection, coinciding with resolution of inflammatory reaction, increased alveolar surfactant pools, and contribution of alveolar ducts to the parenchymal fraction, and a later decrease in the tissue component of the parenchymal fraction. Decreases in tissue damping (resistance) were more marked than decreases in tissue elastance....Continue Reading

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Citations

Apr 14, 2007·American Journal of Respiratory and Critical Care Medicine·J Jane PillowAlan H Jobe
Jan 21, 2014·Pediatric Research·Verena A LambermontBoris W Kramer
Oct 14, 2008·Anaerobe·Alla AroutchevaSebastian Faro
Aug 28, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kanakeswary KarisnanGavin Jon Pinniger
Sep 29, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·V ZanardoS Chiarelli
Aug 29, 2006·Biochemical and Biophysical Research Communications·C RaeS C Land
May 1, 2007·Pediatric Pulmonology·Andreas W FlemmerJan A Deprest
Nov 25, 2005·Pediatric Research·J Jane PillowZoltán Hantos
Nov 5, 2011·Journal of Applied Physiology·Graeme R PolglaseMartin Kluckow
Nov 18, 2005·The Journal of Perinatal & Neonatal Nursing·Barbara S TurnerDebra Brandon
Jan 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alana J WestoverTimothy J M Moss

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