PMID: 11927835Apr 3, 2002Paper

Variability in response to nicotine in the LSxSS RI strains: potential role of polymorphisms in alpha4 and alpha6 nicotinic receptor genes

Pharmacogenetics
Theresa TrittoAllan C Collins

Abstract

Several studies have shown that genetic factors influence the effects of nicotine on respiration, acoustic startle, Y-maze crosses and rears, heart rate and body temperature in the mouse. Recently, we identified restriction fragment length polymorphisms (RFLPs) associated with the alpha4 (Chrna4) and alpha6 (Chrna6) nicotinic cholinergic receptor genes in the recombinant inbred (RI) strains derived from the Long-Sleep (LS) and Short-Sleep (SS) mouse lines. The alpha4 polymorphism has been identified as a point-mutation at position 529 (threonine to alanine) and the alpha6 polymorphism has not yet been identified. The studies described here evaluated the potential role of these polymorphisms in regulating sensitivity to nicotine by constructing dose-response curves for the effects of nicotine on six responses in the LSxSS RI strains. The results obtained suggest that both of the polymorphisms may play a role in regulating variability in sensitivity to nicotine. Those RI strains carrying the LS-like alpha4 RFLP were significantly more sensitive to the effects of nicotine on Y-maze crosses and rears, temperature and respiration and were less sensitive to the effects of nicotine on acoustic startle than those strains carrying the S...Continue Reading

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Citations

Feb 1, 2012·Human Genetics·Allison B Gold, Caryn Lerman
Jun 12, 2013·Biochemical Pharmacology·Michael J Marks
Feb 1, 2003·Trends in Pharmacological Sciences·James W Watters, Howard L McLeod
Feb 25, 2005·Behavioral Neuroscience·Christopher M ButtJerry A Stitzel
Jan 12, 2010·Pharmacogenetics and Genomics·Jennifer A WilkingJerry A Stitzel
Nov 20, 2002·Pharmacogenomics·James W Watters, Howard L McLeod
May 1, 2012·Neuroscience and Biobehavioral Reviews·Harriet de Wit, Tamara J Phillips
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Jeremy C OwensAllan C Collins
May 27, 2003·Alcoholism, Clinical and Experimental Research·Christopher M ButtAllan C Collins
Jan 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marissa A EhringerJoanna S Zeiger
Mar 6, 2004·Pharmacological Reviews·Shelli L Kirstein, Paul A Insel

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