Variability in the response to antiplatelet treatment in diabetes mellitus

Prostaglandins & Other Lipid Mediators
G DavìSimona Sestili

Abstract

Atherothrombosis is a leading cause of death in patients with diabetes mellitus. Among factors contributing to the diabetic prothrombotic state, platelet activation plays a pivotal role. Numerous studies have investigated the benefits of antiplatelet therapy for primary and secondary cardiovascular prevention in diabetic patients. However, there are limited evidences that low-dose aspirin may be effective in this clinical setting. Several disease-specific factors have been identified as potential determinants of aspirin treatment failure. In this review, the main determinants of interindividual variability in response to antiplatelet agents are discussed, with particular emphasis on the pharmacokinetic and pharmacodynamic mechanisms of clinical efficacy and safety of antiplatelet drugs in patients with diabetes mellitus.

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Oct 26, 2012·Critical Reviews in Clinical Laboratory Sciences·Matthew D Linden, Huyen A Tran
May 1, 2012·Journal of Thrombosis and Haemostasis : JTH·M Lordkipanidzé, P Harrison
Feb 7, 2014·Journal of Cardiovascular Medicine·Nuccia MoriciStefano Savonitto
Jun 10, 2019·Journal of Thrombosis and Thrombolysis·Andrea GalloAlessandro Squizzato
Mar 17, 2017·Advances in Nutrition·Jennifer C Kerns, Jean L Gutierrez

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