Variability of cerebral blood flow deficits in 99mTc-HMPAO SPECT in patients with Alzheimer's disease

Journal of Neural Transmission
R ZimmerH Lauter

Abstract

The purpose of this study was to analyse the frequency of the different pathological perfusion patterns in SPECT in a clinical, unselected population of patients with Alzheimer's disease. In 91 patients and 16 control subjects regional cerebral blood flow (rCBF) was measured with Single Photon Emission Computed Tomography (SPECT) using 99mTc-hexa-methyl-propyleneamine oxime (HMPAO). 95% confidence intervals obtained from the perfusion values of the control subjects were used to define normal perfusion ranges. The frequency of perfusion deficits in the left frontal, temporal, parietal and occipital lobes were 62.2%, 60.4%. 70.3% and 23.1%, respectively. In the right hemisphere the corresponding values were 60.4%, 58.2%, 63.7% and 9.9%. With the exception of the occipital lobes these frequencies were not significantly different. The analysis of the perfusion pattern of each patient revealed 35 different combinations of lobes with perfusion deficits. The temporo-parietal perfusion deficits were not more frequent than the temporofrontal perfusion deficits. These results suggest that in the clinical routine a high variety of heterogeneous rCBF patterns have to be expected.

References

Sep 1, 1975·Archives of Neurology·V C HachinskiL Symon
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·J T O'BrienR Levy
Jan 1, 1991·European Journal of Nuclear Medicine·M O HabertS Askienazy
Feb 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T A HurwitzR Brownstone
Jan 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·D MontaldiJ McCulloch
Oct 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·G VallarF Fazio
Feb 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·A BurnsR Levy
Jul 1, 1986·Neurology·R DuaraS I Rapoport
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J V HaxbyS I Rapoport
Dec 1, 1984·Annals of Neurology·N L FosterG Di Chiro
Sep 1, 1982·The American Journal of Psychiatry·B ReisbergT Crook
Mar 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·G WaldemarN A Lassen
Jan 1, 1995·Journal of Neural Transmission. General Section·G StoppeE Rüther

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Citations

Apr 29, 2016·Scientometrics·Juan GorraizThomas Glade

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