PMID: 428824Feb 1, 1979Paper

Variability of gluten intolerance in treated childhood coeliac disease

Gut
B McNichollP F Fottrell

Abstract

Fifty children consecutively attending a clinic for coeliac disease co-operated in a trial; 10 found to have flat mucosa were excluded. Forty children of mean age 9.8 years, whose duodenal or jejunal mucosa had returned to normal or near normal appearance after a mean of 5.8 years on gluten-free diets, were put back on normal diets. In 37, mucosal occurred in a mean of 16.9 months (four to 74 months). Four of the 37 had serial biopsies, in which mucosal enzymes (particularly lactase) fell and interepithelial lymphocyte counts rose before the mucosal morphology was regarded as definitely 'coeliac'. Three children had normal mucosal appearance after 58 to 73 months on normal diets, one of whom showed temporary mucosal abnormalities, another having occasionally low enzymes, in both suggesting underlying gluten sensitivity. Lactase suppression and raised IEL counts appear to be sensitive indicators of gluten intolerance. In our experience, a diagnosis of coeliac disease based on severe mucosal damage and a satisfactory response to a gluten-free but milk-containing diet implies a very strong likelihood of permanent or prolonged gluten intolerance, but with a striking variability in its expression.

References

Sep 1, 1976·The Journal of Pediatrics·B McNichollP F Fottrell
Mar 1, 1975·American Industrial Hygiene Association Journal·A L Linch
Aug 1, 1971·Archives of Disease in Childhood·W F Young, E M Pringle
Aug 1, 1970·Archives of Disease in Childhood·J Walker-Smith
Jan 1, 1968·Analytical Biochemistry·A Dahlqvist
Sep 1, 1968·Clinical Pediatrics·B McNicholl, B Egan

❮ Previous
Next ❯

Citations

Jul 1, 1982·Irish Journal of Medical Science·B Egan-Mitchell, B McNicholl
Oct 19, 1995·The New England Journal of Medicine·E K JanatuinenR J Julkunen
Jul 1, 1980·Archives of Disease in Childhood·B McNichollP F Fottrell
May 1, 1987·Archives of Disease in Childhood·F M StevensB McNicholl
Jul 1, 1987·Archives of Disease in Childhood·J ColacoB McNicholl
Mar 1, 1994·Archives of Disease in Childhood·M T BardellaP A Bianchi
Jan 1, 1981·Gut·B Egan-MitchellB McNicholl
Apr 1, 1981·Journal of Clinical Pathology·F J PennaM Shiner
Jan 1, 1988·Scandinavian Journal of Gastroenterology·A PaerregaardE Gudmand-Høyer
Feb 4, 1998·Baillière's Clinical Gastroenterology·C Catassi, E Fabiani
Mar 1, 1986·Acta paediatrica Scandinavica·P KuitunenM Verkasalo
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Rachele Ciccocioppo, Gino Roberto Corazza
Jan 1, 1982·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·H WieserD Idar
Dec 1, 1982·European Journal of Pediatrics·S MusumeciG Bottaro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.