Variability of Gross Tumor Volume Delineation for Stereotactic Body Radiotherapy of the Lung With Tri-60 Co Magnetic Resonance Image-Guided Radiotherapy System (ViewRay): A Comparative Study With Magnetic Resonance- and Computed Tomography-Based Target Delineation

Technology in Cancer Research & Treatment
Chan Woo WeeHong-Gyun Wu

Abstract

To evaluate the intra-/interobserver variability of gross target volumes between delineation based on magnetic resonance imaging and computed tomography in patients simulated for stereotactic body radiotherapy for primary lung cancer and lung metastasis. Twenty-five patients (27 lesions) who underwent computed tomography and magnetic resonance simulation with the MR-60Co system (ViewRay) were included in the study. Gross target volumes were delineated on the magnetic resonance imaging (GTVMR) and computed tomography (GTVCT) images by 2 radiation oncologists (RO1 and RO2). Volumes of all contours were measured. Levels of intraobserver (GTVMR_RO vs GTVCT_RO) and interobserver (GTVMR_RO1 vs GTVMR_RO2; GTVCT_RO1 vs GTVCT_RO2) agreement were evaluated using the generalized κ statistics and the paired t test. No significant volumetric difference was observed between all 4 comparisons (GTVMR_RO1 vs GTVCT_RO1, GTVMR_RO2 vs GTVCT_RO2, GTVMR_RO1 vs GTVMR_RO2, and GTVCT_RO1 vs GTVCT_RO2; P > .05), with mean volumes of GTVs ranging 5 to 6 cm3. The levels of agreement between those 4 comparisons were all substantial with mean κ values of 0.64, 0.66, 0.74, and 0.63, respectively. However, the interobserver agreement level was significantly h...Continue Reading

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Citations

Oct 28, 2019·Journal of Medical Imaging and Radiation Oncology·Stephen ChinAnanya Choudhury
Oct 22, 2019·Frontiers in Oncology·Kendall J KiserClifton D Fuller
Nov 2, 2019·Hematology/oncology Clinics of North America·Sonja StiebClifton David Fuller
Nov 12, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tobias FinazziSuresh Senan

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Methods Mentioned

BETA
surgical resection

Software Mentioned

ViewRay
Statistical Package for Social Sciences
Eclipse Environment for Research
Eclipse

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