Variability of gross tumor volume delineation in head-and-neck cancer using CT and PET/CT fusion

International Journal of Radiation Oncology, Biology, Physics
Adam C RiegelPing S Wong

Abstract

To assess the need for gross tumor volume (GTV) delineation protocols in head-and-neck cancer (HNC) treatment planning by use of positron emission tomography (PET)/computed tomography (CT) fusion imaging. Assessment will consist of interobserver and intermodality variation analysis. Sixteen HNC patients were accrued for the study. Four physicians (2 neuroradiologists and 2 radiation oncologists) contoured GTV on 16 patients. Physicians were asked to contour GTV on the basis of the CT alone, and then on PET/CT fusion. Statistical analysis included analysis of variance for interobserver variability and Student's paired sample t test for intermodality and interdisciplinary variability. A Boolean pairwise analysis was included to measure degree of overlap. Near-significant variation occurred across physicians' CT volumes (p = 0.09) and significant variation occurred across physicians' PET/CT volumes (p = 0.0002). The Boolean comparison correlates with statistical findings. One radiation oncologist's PET/CT fusion volumes were significantly larger than his CT volumes (p < 0.01). Conversely, the other radiation oncologist's CT volumes tended to be larger than his fusion volumes (p = 0.06). No significant interdisciplinary variation w...Continue Reading

References

May 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·C S HamiltonP V Bydder
Nov 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G LeunensE van der Schueren
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·C H KettingJ Jacky
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·J P LogueD Mott
Jul 29, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C FiorinoR Calandrino
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·P TaiT Coad
Feb 16, 1999·International Journal of Radiation Oncology, Biology, Physics·C RaschJ V Lebesque
Mar 4, 2000·International Journal of Radiation Oncology, Biology, Physics·R MohanR Schmidt-Ullrich
Jun 28, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A E SaarnakM J Steggerda
Dec 29, 2000·Medical Physics·R A Siochi
Jun 19, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C WeltensE van der Schueren
Feb 7, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan Van de SteeneGuy Storme
Jun 5, 2002·Current Oncology Reports·Rakesh R Patel, Minesh Mehta
May 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elisabeth WeissClemens F Hess
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Nancy LeeJeanne M Quivey
Oct 8, 2003·International Journal of Radiation Oncology, Biology, Physics·I Frank CiernikGustav K Von Schulthess
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Charlotte E ColesMichael V Williams
Apr 20, 2004·International Journal of Radiation Oncology, Biology, Physics·Jeffrey BradleyRudi J Bertrand
Oct 13, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L LicitraP Bossi
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Jacqueline E LivseyJohn P Logue
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Dwight E HeronNorbert Avril
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Arnold C PaulinoLawrence W Davis

❮ Previous
Next ❯

Citations

Aug 14, 2008·Australasian Physical & Engineering Sciences in Medicine·Z BradyJ V Trapp
Feb 20, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Liselotte Højgaard, Lena Specht
Mar 26, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Habib Zaidi, Issam El Naqa
Apr 5, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Dominic A X SchinaglJohannes H A M Kaanders
Apr 2, 2008·Current Oncology Reports·June CorryLester J Peters
Aug 7, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Luis Alberto Perez-RomasantaJoaquin Velasco-Jimenez
Jul 4, 2012·The Lancet Oncology·Vincent GrégoireBrian O'Sullivan
Jan 5, 2013·Journal of Radiation Research·Chikae KajitaniMasatoshi Hasegawa
Apr 27, 2007·Nuclear Medicine Communications·Jorn A van DalenWim J G Oyen
May 10, 2011·Clinical Nuclear Medicine·Guang-Uei HungMu-Kuan Chen
Jun 28, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Anne Kiil BerthelsenAndré Wambersie
Sep 20, 2008·Radiation Oncology·Letizia DeantonioMarco Krengli
Feb 26, 2013·AJR. American Journal of Roentgenology·Jessica DavisonRathan M Subramaniam
Oct 17, 2008·Future Oncology·Yaacov Richard LawrenceAdam P Dicker
Sep 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eric C FordRichard L Wahl
Jan 21, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D GenovesiM Di Nicola
Dec 17, 2008·Medical Physics·Tinsu Pan, Osama Mawlawi
Sep 21, 2011·Radiology·Stephanie A TerezakisBilly W Loo
Aug 15, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Dominic A X SchinaglJohannes H A M Kaanders
Jun 2, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·M DimigenK Lim
Nov 15, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Priya BhatnagarAndrew F Scarsbrook
Dec 3, 2014·PET Clinics·Christina K SpeirsJeffrey D Bradley
Oct 1, 2014·Cancers·Andrea GallaminiAnna Borra
Sep 6, 2013·Acta Oncologica·Bianca A W HoebenJohannes H A M Kaanders
Jan 20, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Gianpiero MancaDuccio Volterrani
May 16, 2012·International Journal of Radiation Oncology, Biology, Physics·Mary FengJames M Balter
Sep 19, 2012·Current Problems in Cancer·Heath D SkinnerBeth M Beadle
Aug 21, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Tony YoungLois Holloway
May 18, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·R J D PrestwichA F Scarsbrook
Mar 20, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C RossierJ O Prior
Jul 12, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D RobergeC Freeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.