PMID: 2493043Mar 1, 1989Paper

Variability of indexes for myocardial ischemia: a comparison of exercise treadmill test, ambulatory electrocardiographic monitoring and symptoms of myocardial ischemia

Journal of the American College of Cardiology
K NademaneeF V Mody

Abstract

Fifty-four patients with chronic stable angina were studied to determine and compare weekly variability of indexes for the detection of myocardial ischemia. All patients underwent three single-blind placebo periods, each lasting 1 week. An exercise treadmill test, 24 h ambulatory electrocardiographic (Holter) monitoring (analyzed blindly) and an accurate diary of anginal attacks and nitroglycerin use were obtained at the end of each placebo period. An unbalanced, completely random component of variance analysis was used to calculate a component for within subject variability and a component for among subject variability. The coefficient of variation and percent variation (within subjects) of onset of chest pain during exercise were 19% and 30%, respectively; the corresponding values were 28% and 33% for onset of 1 mm ST depression, 15% and 15% for exercise duration, 44% and 27% for number of ischemic episodes/24 h, 56% and 43% for anginal frequency and 55% and 27% for nitroglycerin consumption, respectively. With use of this statistical method and variation within subjects, the change in the value of each variable necessary to exceed those attributable to spontaneous variation was determined. The trade-off between repeated meas...Continue Reading

References

Dec 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·C Lassvik
Aug 15, 1986·The American Journal of Cardiology·V Bala Subramanian
Jul 1, 1987·Journal of the American College of Cardiology·K NademaneeB N Singh
Nov 1, 1987·The American Journal of Cardiology·D TzivoniS Stern
Aug 1, 1986·The American Journal of Cardiology·C R LambertC J Pepine
Aug 15, 1986·The American Journal of Cardiology·D TzivoniS Stern
Nov 1, 1985·Journal of the American College of Cardiology·D D WatersP A Crean
Dec 1, 1984·The American Journal of Cardiology·J E DeanfieldA P Selwyn
Feb 1, 1984·American Heart Journal·M R StarlingR A O'Rourke
Jun 1, 1980·British Heart Journal·A Maseri

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Citations

Jun 1, 1996·Pacing and Clinical Electrophysiology : PACE·M S FullerR Lux
Dec 1, 1994·The American Journal of Cardiology·M C PortegiesK I Lie

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