Abstract
The levels of many laboratory parameters are associated with the outcomes of dialysis patients, but the significance of their variability has not been well studied. A total of 384 patients receiving stable hemodialysis treatment during 2002 were followed up for mortality until the end of 2013. The within-patient coefficients of variation (CV) were calculated for 13 laboratory parameters from 1 year of data. We defined variability as CV and analyzed the survival of the patients according to the baseline CV values of each parameter by proportional hazard modeling. During the 11-year observation period, 125 patients died. Higher CV levels for eight parameters, namely, blood urea nitrogen (BUN), sodium, hemoglobin, creatinine, total protein, albumin, potassium and phosphate, were significantly associated with all-cause mortality. The adjusted hazard ratios for a high BUN-CV (>15 %) and a high Na-CV (>1.3 %) against a lower CV were 1.92 (95 % CI 1.31-2.81) and 1.95 (1.36-2.80), respectively. The increased mortality risk associated with each variability was attributed to excess non-cardiac deaths. The CV values of most parameters were correlated with each other and often exhibited negative associations with age, diabetes, and mobilit...Continue Reading
References
Aug 1, 1997·Artificial Organs·T ShinzatoK Maeda
Mar 21, 1998·Kidney International·A R QureshiJ Bergström
Apr 16, 2002·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Jerrilynn D BurrowesDiane Poole
Mar 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon DesmeulesBernard Canaud
Mar 8, 2007·Kidney International·M M H HermansUNKNOWN Netherlands cooperative study on the adequacy of Dialysis (NECOSAD)
Jun 15, 2007·Bone Marrow Transplantation·L ScruccaF Aversa
Sep 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nathalie TerrierJean-Paul Cristol
Jul 1, 2009·Nephrology·Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Jul 9, 2009·Hemodialysis International·Amar A DesaiBrennan M R Spiegel
Mar 2, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michal ChmielewskiFriedo W Dekker
Jul 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Bernard CanaudFriedrich K Port
Jun 1, 2013·The Journal of Clinical Investigation·Helge WiigJens Titze
Jun 5, 2013·Journal of Psychosomatic Research·Sandra van DijkUNKNOWN NECOSAD Study Group
Jun 7, 2013·Kidney International·Leonard M EbahSandip Mitra
Aug 8, 2014·Kidney International·Anke DahlmannJens M Titze
Aug 28, 2014·Frontiers in Physiology·Angelica M MerlotDes R Richardson
Sep 10, 2014·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Xavier Moreau-GaudryDenis Fouque
Citations
Jul 10, 2016·Clinical and Experimental Nephrology·Daijo InagumaHibiki Shinjo
Oct 13, 2018·Geriatrics & Gerontology International·Yuki KakioJun Wada
Sep 28, 2017·PloS One·Yuichi NakazatoHiromi Shimoyama
Nov 28, 2019·Circulation. Cardiovascular Interventions·Nobuyoshi AzumaOsamu Iida
Oct 11, 2017·PloS One·Sunny ElootGriet Glorieux
Jul 31, 2020·PloS One·Karsten Vanden WyngaertAmaryllis H Van Craenenbroeck
Sep 29, 2020·Frontiers in Medicine·Chia-Ming LiKuo-Chin Huang
Jun 27, 2020·Scientific Reports·Yuichi NakazatoHiromi Shimoyama
Aug 7, 2018·The Journal of Nutrition, Health & Aging·D H SullivanS Y Lensing
Jul 16, 2020·International Journal of Nephrology·Eirini PalakaOliver Darlington
Nov 24, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hong Joon ParkSanghyun Park
Nov 19, 2020·JAMA Cardiology·Matthew W SegarAmbarish Pandey
Apr 10, 2021·Frontiers in Pharmacology·Jayandiran PillaiDebashis Basu