Variability of laminin isoforms in the limbus region of the eye

Klinische Monatsblätter für Augenheilkunde
T S DietleinG K Krieglstein

Abstract

Cell adhesion in the limbal region is of outstanding importance for the regeneration of the corneal epithelium and for repair mechanisms after antiglaucomatous fistulating surgery. In the basement membranes cell adhesion is largely modified by the extracellular matrix protein laminin. The aim of our study was to establish the immunohistochemical pattern of the different laminin-isoforms and subunits in the basal membrane of the limbal conjunctiva and episcleral vessels. For immunohistochemistry five normal human donor eyes were included; we used antibodies against the laminin heterotrimers 1 and 2, against the laminin subunits alpha 2, beta 1, beta 2, gamma 1, gamma 2 and against the laminin-associated protein nidogen. The basement membrane of the limbal conjunctiva reveals immunoreactivity against all used antibodies. The subconjunctival and episcleral vessels showed no staining for the laminin subunit gamma 2, but for all other used antibodies. The basement membrane of the limbal and conjunctival epithelium as well as the basement membrane of subconjunctival and episcleral vessels express a broad spectrum of laminin variants. This diversity emphasizes functional specialization of the limbal region, although the exact importan...Continue Reading

Citations

Oct 12, 2007·Experimental Eye Research·U Schlötzer-SchrehardtF E Kruse
Jul 30, 2005·Experimental Eye Research·Ursula Schlötzer-Schrehardt, Friedrich E Kruse
Jan 1, 2012·Journal of Functional Biomaterials·Hua MeiSophie X Deng
Jul 20, 2007·Cell Proliferation·R P RevoltellaM Michelini

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